PMID- 35436277
OWN - NLM
STAT- MEDLINE
DCOM- 20220420
LR  - 20220420
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 50
IP  - 296
DP  - 2022 Apr 19
TI  - [Diagnostic challenges in Kimura's disease].
PG  - 128-130
AB  - Ultra-rare diseases occur with a frequency of 2 in 100 000 people or less. 
      Kimura's disease (KD) affects less than 1 in 1 000 000 people. It is a benign, 
      chronic inflammatory soft tissue disorder, accompanied by eosinophilia, raised 
      immunoglobulin E (IgE) titer and the presence of painless subcutaneous masses, 
      usually in the head and neck region. The disease was first described in 1948 and 
      occurs at higher rates in Asia than in America or Europe. A CASE REPORT: A 
      35-year-old man without past medical history presented to his family doctor for 
      bilateral cervical lymphadenopathy accompanied by eosinophilia. Despite 
      subsequent in-depth diagnostics, including fine-needle aspiration biopsy (FNAB) 
      of the lymph nodes, the definitive diagnosis was not initially established. After 
      following 2 months, a selective lymphadenectomy was performed, putting Hodgkin's 
      lymphoma under suspicion. The image of positron emission tomography coupled with 
      computed tomography (PET-CT) corresponded to this diagnosis. Due to the lack of 
      all the criteria necessary to make a diagnosis, another histopathological 
      consultation was done. The image of the lymph nodes suggested 
      reaction-inflammatory changes. Due to the presence of a triad of signs (reactive 
      lymphadenopathy, several eosinophils in the paracortic zone, vascular 
      proliferation), differential diagnosis was recommended, among others towards the 
      Kimura's disease. A series of examinations allowed to exclude lymphadenopathy of 
      parasitic, allergic and hyperplastic hematopoietic system aetiology. The patient 
      started steroid therapy with a good effect at first. However, after the 
      recurrence of the disease, the patient was qualified to intensify the 
      immunosuppressive treatment. CONCLUSIONS: In the described case, the intensive 
      diagnostic process and the thorough analysis of the test results relatively 
      quickly led to the correct diagnosis. This enabled the implementation of 
      appropriate treatment and prevented the initiation of empirical therapy for the 
      originally diagnosed Hodgkin's lymphoma.
CI  - (c) 2022 MEDPRESS.
FAU - Stuczynski, Sebastian Krzysztof
AU  - Stuczynski SK
AD  - Medical University of Lodz, Poland: Student Scientific Society affiliated with 
      the Department of Nephrology, Hypertension and Kidney Transplantation.
FAU - Muras-Szwedziak, Katarzyna
AU  - Muras-Szwedziak K
AD  - Medical University of Lodz, Poland: Department of Nephrology, Hypertension and 
      Kidney Transplantation.
FAU - Nowicki, Michal
AU  - Nowicki M
AD  - Medical University of Lodz, Poland: Department of Nephrology, Hypertension and 
      Kidney Transplantation.
LA  - pol
PT  - Case Reports
PT  - Journal Article
TT  - Wyzwania w diagnostyce choroby Kimury.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
SB  - IM
MH  - Adult
MH  - *Angiolymphoid Hyperplasia with Eosinophilia/complications/diagnosis/therapy
MH  - *Hodgkin Disease/complications/diagnosis/therapy
MH  - Humans
MH  - *Kimura Disease/diagnosis
MH  - *Lymphadenopathy/complications/etiology
MH  - Male
MH  - Positron Emission Tomography Computed Tomography/adverse effects
OTO - NOTNLM
OT  - Kimura's disease
OT  - lymphadenopathy
OT  - rare disease
EDAT- 2022/04/19 06:00
MHDA- 2022/04/21 06:00
CRDT- 2022/04/18 17:10
PHST- 2022/04/18 17:10 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/21 06:00 [medline]
AID - PML296-128 [pii]
PST - ppublish
SO  - Pol Merkur Lekarski. 2022 Apr 19;50(296):128-130.