PMID- 35437007
OWN - NLM
STAT- MEDLINE
DCOM- 20220420
LR  - 20220716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Apr 18
TI  - Biochemical abnormalities among patients referred for celiac disease antibody 
      blood testing in a primary health care setting.
PG  - 6407
LID - 10.1038/s41598-022-10492-6 [doi]
LID - 6407
AB  - To investigate possible biochemical abnormalities associated with celiac disease 
      (CD) antibody positivity in a primary health care setting and thereby identify 
      predictors that could potentially reduce diagnostic delay and underdiagnosis of 
      CD. This observational cohort study included measurements of CD antibodies in the 
      Copenhagen Primary Care Laboratory (CopLab) database from 2000 to 2015; CD 
      antibody positivity was defined as tissue transglutaminase antibody IgA or 
      IgG >/= 7 kU/L and/or deamidated gliadin peptide antibody IgG >/= 10 kU/L. 
      Individuals with a prior diagnosis of CD were excluded. We examined differences 
      between individuals with positive and negative CD antibody tests regarding the 
      results of biochemical tests performed six months before and one month after the 
      date of the CD antibody test. We identified 76,265 measurements of CD antibodies 
      during 2000-2015, and 57,061 individuals met the inclusion criteria (706 
      antibody-positive and 56,355 antibody-negative). We found lower ferritin, 
      hemoglobin, cobalamin and folic acid levels and higher levels of transferrin, 
      ALAT (alanine transaminase), and alkaline phosphate among individuals with a 
      positive CD antibody test. Furthermore, we illustrated more measurements below 
      the sex-specific reference intervals for hemoglobin, mean corpuscular volume 
      (MCV), mean corpuscular hemoglobin concentration (MCHC), ferritin, cobalamin and 
      folic acid among individuals with a positive CD antibody test. This study 
      identified several biochemical abnormalities associated with CD antibody 
      positivity among individuals referred to CD antibody testing. The pattern of 
      abnormalities suggested that micronutrient deficiencies were prevalent among CD 
      antibody-positive individuals, confirming malabsorption as a sign of CD. These 
      findings illustrate the possibility of reducing diagnostic delay and 
      underdiagnosis of CD.
CI  - (c) 2022. The Author(s).
FAU - Karhus, Line Lund
AU  - Karhus LL
AD  - Center for Clinical Research and Prevention, Copenhagen University Hospital - 
      Bispebjerg and Frederiksberg, Frederiksberg, Copenhagen, Denmark. 
      line.lund.kaarhus@regionh.dk.
FAU - Kriegbaum, Margit
AU  - Kriegbaum M
AD  - Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General 
      Practice and Section of General Practice, Department of Public Health, University 
      of Copenhagen, Copenhagen, Denmark.
FAU - Grand, Mia Klinten
AU  - Grand MK
AD  - Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General 
      Practice and Section of General Practice, Department of Public Health, University 
      of Copenhagen, Copenhagen, Denmark.
FAU - Lind, Bent Struer
AU  - Lind BS
AD  - Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, 
      Hvidovre, Denmark.
FAU - Mollehave, Line Tang
AU  - Mollehave LT
AD  - Center for Clinical Research and Prevention, Copenhagen University Hospital - 
      Bispebjerg and Frederiksberg, Frederiksberg, Copenhagen, Denmark.
FAU - Rumessen, Juri J
AU  - Rumessen JJ
AD  - Department of Gastroenterology, Copenhagen University Hospital - Herlev and 
      Gentofte, Copenhagen, Denmark.
FAU - Andersen, Christen Lykkegaard
AU  - Andersen CL
AD  - Copenhagen Primary Care Laboratory (CopLab) Database, Research Unit for General 
      Practice and Section of General Practice, Department of Public Health, University 
      of Copenhagen, Copenhagen, Denmark.
AD  - Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
FAU - Linneberg, Allan
AU  - Linneberg A
AD  - Center for Clinical Research and Prevention, Copenhagen University Hospital - 
      Bispebjerg and Frederiksberg, Frederiksberg, Copenhagen, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220418
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 9007-73-2 (Ferritins)
RN  - 9007-90-3 (Gliadin)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Autoantibodies
MH  - *Celiac Disease
MH  - Delayed Diagnosis
MH  - Female
MH  - Ferritins
MH  - Folic Acid
MH  - Gliadin
MH  - Humans
MH  - Immunoglobulin A
MH  - Immunoglobulin G
MH  - Male
MH  - Primary Health Care
MH  - Sensitivity and Specificity
MH  - Transglutaminases
MH  - Vitamin B 12
PMC - PMC9016061
COIS- LLK has received honoraria for a lecture from ThermoFisher Scietific, the payment 
      was made to Center for Clinical Research and Prevention. All other authors have 
      no conflict of interest.
EDAT- 2022/04/20 06:00
MHDA- 2022/04/21 06:00
PMCR- 2022/04/18
CRDT- 2022/04/19 05:40
PHST- 2021/10/13 00:00 [received]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/04/19 05:40 [entrez]
PHST- 2022/04/20 06:00 [pubmed]
PHST- 2022/04/21 06:00 [medline]
PHST- 2022/04/18 00:00 [pmc-release]
AID - 10.1038/s41598-022-10492-6 [pii]
AID - 10492 [pii]
AID - 10.1038/s41598-022-10492-6 [doi]
PST - epublish
SO  - Sci Rep. 2022 Apr 18;12(1):6407. doi: 10.1038/s41598-022-10492-6.