PMID- 35437851
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220716
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 44
IP  - 7
DP  - 2022 Jul
TI  - Systematic review of neuroendocrine carcinomas of the oropharynx.
PG  - 1725-1736
LID - 10.1002/hed.27055 [doi]
AB  - Data describing features and management of oropharyngeal neuroendocrine 
      carcinomas (NEC) remain sparse. A systematic review was performed. Patients were 
      stratified by treatment modality and examined for disease progression and 
      survival outcomes. Ninety-four patients from 50 publications were included. 
      Average age at diagnosis was 59.7 years (range 14-83). 73.4% were male. Most 
      studies did not document HPV status. Forty patients (85.1%) were p16 positive, 
      and 34 (85.0%) were HPV-ISH positive. Overall survival was 75.4% at 1 year, and 
      40.0% at 2 years. Of patients with locoregional disease, 33.8% developed distant 
      metastasis. 12.5% of patients developed locoregional recurrence. Patients who 
      developed distant metastases had worse overall survival (p = 0.0004). No 
      significant difference was found between treatment modalities. Human papilloma 
      virus may be associated with oropharyngeal NEC. Current treatments provide 
      locoregional control, but distant metastases are common and confer low overall 
      survival.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Froehlich, Michael H
AU  - Froehlich MH
AUID- ORCID: 0000-0002-3606-6891
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Shih, Michael C
AU  - Shih MC
AUID- ORCID: 0000-0002-2972-637X
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Shehee, Lindsey
AU  - Shehee L
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Kompelli, Anvesh R
AU  - Kompelli AR
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
AD  - Department of Otolaryngology - Head and Neck Surgery, Louisiana State University 
      Health Sciences Center, New Orleans, Louisiana, USA.
FAU - Aylward, Alana
AU  - Aylward A
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Nguyen, Shaun A
AU  - Nguyen SA
AUID- ORCID: 0000-0003-0664-4571
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Kaczmar, John M
AU  - Kaczmar JM
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Nathan, Cherie Ann
AU  - Nathan CA
AD  - Department of Otolaryngology - Head and Neck Surgery, Louisiana State University 
      Health Sciences Center, New Orleans, Louisiana, USA.
FAU - Day, Terry
AU  - Day T
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
FAU - Neskey, David M
AU  - Neskey DM
AD  - Department of Otolaryngology - Head and Neck Surgery, Medical University of South 
      Carolina, Charleston, South Carolina, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220418
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carcinoma, Neuroendocrine/secondary/therapy
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - *Oropharyngeal Neoplasms/pathology
MH  - Papillomaviridae
MH  - *Papillomavirus Infections/complications
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - chemotherapy
OT  - evidence-based medicine
OT  - neuroendocrine carcinoma
OT  - oropharynx
OT  - radiation therapy
EDAT- 2022/04/20 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/04/19 06:03
PHST- 2022/01/15 00:00 [revised]
PHST- 2021/09/27 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/04/20 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/04/19 06:03 [entrez]
AID - 10.1002/hed.27055 [doi]
PST - ppublish
SO  - Head Neck. 2022 Jul;44(7):1725-1736. doi: 10.1002/hed.27055. Epub 2022 Apr 18.