PMID- 35439871
OWN - NLM
STAT- MEDLINE
DCOM- 20220421
LR  - 20220421
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 40
IP  - 3
DP  - 2022 Mar 20
TI  - [Research progress of C-X-C motif chemokine ligand 12 and its receptor signaling 
      axis in the regulation of pulmonary fibrosis].
PG  - 235-240
LID - 10.3760/cma.j.cn121094-20210413-00196 [doi]
AB  - Pulmonary fibrosis is an irreversible interstitial lung disease characterized by 
      lung parenchyma remodeling and collagen deposition. In recent years, the 
      incidence and mortality of pulmonary fibrosis caused by unknown causes have 
      risen. However, its pathogenesis is still unclear. C-X-C motif chemokine ligand 
      12 (CXCL12)/C-X-C chemokine receptor 4 (CXCR4)/CXCR7 signal axis plays a critical 
      regulatory role in pulmonary fibrosis disease. In addition, the signal axis has 
      been shown to regulate recruitment and migration of circulating fibrocytes, 
      mesenchymal stem cells to the damage lung tissue, the migration of endothelial 
      cells, the proliferation and differentiation of fibroblasts and endothelial 
      cells, which further affects the occurrence and progression of pulmonary 
      fibrosis. In this review, we summarized the pathogenesis and treatment research 
      progress of CXCL12 and its receptor CXCR4/CXCR7 in the occurrence and progression 
      of pulmonary fibrosis.
FAU - Sun, Q X
AU  - Sun QX
AD  - School of Medicine, Anhui University of Science and Technology, Huainan 232001, 
      China; Key Laboratory of Industrial Dust Prevention and Control & Occupational 
      Health and Safety, Ministry of Education, Anhui University of Science and 
      Technology, Huainan 232001, China.
FAU - Mu, M
AU  - Mu M
AD  - School of Medicine, Anhui University of Science and Technology, Huainan 232001, 
      China; Key Laboratory of Industrial Dust Prevention and Control & Occupational 
      Health and Safety, Ministry of Education, Anhui University of Science and 
      Technology, Huainan 232001, China.
FAU - Tao, X R
AU  - Tao XR
AD  - School of Medicine, Anhui University of Science and Technology, Huainan 232001, 
      China; Key Laboratory of Industrial Dust Prevention and Control & Occupational 
      Health and Safety, Ministry of Education, Anhui University of Science and 
      Technology, Huainan 232001, China.
LA  - chi
GR  - GXXT-2021-077/The University Synergy Innovation Program of Anhui Province/
GR  - KJ2019ZD13 , KJ2019A0131, KJ2019A0132/Natural Science Foundation of Anhui 
      Province/
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Ligands)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Chemokine CXCL12
MH  - Endothelial Cells/pathology
MH  - Humans
MH  - Ligands
MH  - Lung/pathology
MH  - *Pulmonary Fibrosis/pathology
MH  - Receptors, CXCR4
OTO - NOTNLM
OT  - C-X-C motif chemokine ligand 12 (CXCL12)
OT  - Inhibitor
OT  - Pulmonary fibrosis
OT  - Receptor
EDAT- 2022/04/20 06:00
MHDA- 2022/04/22 06:00
CRDT- 2022/04/19 22:49
PHST- 2022/04/19 22:49 [entrez]
PHST- 2022/04/20 06:00 [pubmed]
PHST- 2022/04/22 06:00 [medline]
AID - 10.3760/cma.j.cn121094-20210413-00196 [doi]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Mar 20;40(3):235-240. doi: 
      10.3760/cma.j.cn121094-20210413-00196.