PMID- 35440194
OWN - NLM
STAT- MEDLINE
DCOM- 20220421
LR  - 20220421
IS  - 0040-5930 (Print)
IS  - 0040-5930 (Linking)
VI  - 79
IP  - 3-4
DP  - 2022 Apr
TI  - [GERD and Barett: Natural Course of One Disease - Update Diagnostics and 
      Therapy].
PG  - 151-158
LID - 10.1024/0040-5930/a001342 [doi]
AB  - GERD and Barett: Natural Course of One Disease - Update Diagnostics and Therapy 
      Abstract. The gastroesophageal reflux disease (GERD) represents a relatively 
      frequent condition, which clinically includes orocervical, thoracic and abdominal 
      complaints. GERD is defined as pathological gastroesophageal acidic reflux, which 
      consecutively leads to mucosal damage of the esophagus such as reflux 
      esophagitis. The most common symptom of GERD is heartburn but GERD symptoms 
      include various complaints, which need to be considered in diagnosis and therapy. 
      Besides endoscopy, barium swallow, pH metry and manometry are counted among the 
      routine diagnostics for GERD patients. For therapy, dietary and lifestyle 
      measures come along with medication such as proton pump inhibitors (PPI) as daily 
      medication and antacids on demand. It has been demonstrated that anti-reflux 
      surgery, minimally invasive fundoplication or magnet augmentation of the lower 
      esophageal sphincter, produces an equal and lasting effect on GERD compared to 
      PPI. Surgery is preferred in case of large hiatal hernia of voluminous reflux. 
      Success of therapy is given if esophageal exposure to acid is reduced, which 
      shows in remission of esophagitis or which can be demonstrated through pH-metry 
      control. Additionally, improvement of quality of life stands in the focus of GERD 
      treatment, which is to be considered for every therapeutic step. Barrett 
      esophagus represents a subtype of GERD with rising incidence in Western 
      countries. As potential precancerous lesion, the Barrett's esophagus is to be 
      diagnosed early and needs to undergo a risk stratified surveillance in order to 
      prevent dysplasia or carcinoma. Patients with low grade dysplasia, high grade 
      dysplasia or early Barrett's carcinoma should be treated endoscopically. Soon 
      artificial intelligence might contribute to improvement of Barrett's esophagus 
      surveillance and treatment.
FAU - Berlth, Felix
AU  - Berlth F
AD  - Klinik fur Allgemein-, Viszeral- und Transplantationschirurgie, Unimedizin der 
      Johannes-Gutenberg-Universitat, Mainz, Deutschland.
FAU - Lorenz, Florian
AU  - Lorenz F
AD  - Klinik fur Gastroenterologie und Hepatologie, Uniklinik Koln, Deutschland.
FAU - Kleinert, Robert
AU  - Kleinert R
AD  - Klinik fur Allgemein- und Viszeralchirugie, Evangelisches Klinikum Bethel, 
      Universitatsklinikum OWL der Universitat Bielefeld, Campus Bielefeld-Bethel, 
      Deutschland.
FAU - Langhammer, Nils
AU  - Langhammer N
AD  - Viszeral-, Thorax-, Kinder- & Endokrine Chirurgie Johannes Wesling Klinikum 
      Minden, Universitatsklinikum der Ruhr Universitat Bochum, Minden, Deutschland.
FAU - Hadzijusufovic, Edin
AU  - Hadzijusufovic E
AD  - Klinik fur Allgemein-, Viszeral- und Transplantationschirurgie, Unimedizin der 
      Johannes-Gutenberg-Universitat, Mainz, Deutschland.
FAU - Chon, Seung-Hun
AU  - Chon SH
AD  - Klinik fur Allgemein-, Viszeral-, Tumor und Transplantationschirurgie, Uniklinik 
      Koln, Deutschland.
LA  - ger
PT  - Journal Article
TT  - GERD und Barrett.
PL  - Switzerland
TA  - Ther Umsch
JT  - Therapeutische Umschau. Revue therapeutique
JID - 0407224
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Artificial Intelligence
MH  - *Barrett Esophagus/diagnosis/pathology/therapy
MH  - *Carcinoma/complications/drug therapy
MH  - *Gastroesophageal Reflux/diagnosis/etiology/therapy
MH  - Humans
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Quality of Life
EDAT- 2022/04/21 06:00
MHDA- 2022/04/22 06:00
CRDT- 2022/04/20 05:21
PHST- 2022/04/20 05:21 [entrez]
PHST- 2022/04/21 06:00 [pubmed]
PHST- 2022/04/22 06:00 [medline]
AID - 10.1024/0040-5930/a001342 [doi]
PST - ppublish
SO  - Ther Umsch. 2022 Apr;79(3-4):151-158. doi: 10.1024/0040-5930/a001342.