PMID- 35443576
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220531
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 68
IP  - 4
DP  - 2022 Apr 1
TI  - Vitamin D and Hypoxia-Inducible Factor (HIF-1alpha) Serum Levels as Markers for 
      Progression of Nephropathy in Type 2 Diabetic Patients.
LID - 10.7754/Clin.Lab.2021.210540 [doi]
AB  - BACKGROUND: Vitamin D is a locally acting hormone, which plays a major role in 
      skeletal health. Previous studies reported an important role of vitamin D in 
      modulation of inflammatory response. We aimed to investigate the role of vitamin 
      D deficiency and hypoxia-inducible factor (HIF-1alpha) as markers for the progression 
      of diabetic nephropathy in Saudi patients with type 2 diabetes mellitus (T2DM). 
      METHODS: We included 174 Saudi patients with T2DM in addition to 60 healthy 
      control subjects. Patients were classified according to urinary Albumin to 
      Creatinine Ratio (ACR) into three groups: Group AI: ACR < 30 microg/mg, Group AII: 
      ACR levels of 30 - 300 microg/mg and Group AIII: ACR > 300 microg/mg. We estimated 
      fasting blood glucose, HbA1c, lipid profile, serum creatinine, hemoglobin 
      concentration (Hb), estimated glomerular filtration rate (eGFR), urine 
      albumin/creatinine ratio, serum 25 hydroxyvitamin D, calcium, parathyroid hormone 
      (PTH), tumor necrosis factor (TNF-alpha), C- reactive protein (CRP), and 
      hypoxia-inducible factor (HIF-1alpha). RESULTS: There was a significant difference 
      among studied groups regarding serum levels of vitamin D, calcium, PTH, TNF-alpha, 
      CRP, and HIF-1alpha levels. The level of vitamin D was lower in diabetic patients in 
      comparison to the controls and was significantly related to the severity of renal 
      nephropathy as indicated by the level of albumin in urine. Moreover, vitamin D 
      levels showed significant negative correlation with the inflammatory markers: 
      TNF-alpha, CRP, and HIF-1alpha levels. CONCLUSIONS: Vitamin D deficiency and elevated 
      HIF-1alpha serum levels showed a significant correlation to progression of 
      nephropathy in Saudi patients with T2DM.
FAU - Gharib, Amal F
AU  - Gharib AF
FAU - Askary, Ahmad El
AU  - Askary AE
FAU - Almehmadi, Mazen
AU  - Almehmadi M
FAU - Etewa, Rasha L
AU  - Etewa RL
FAU - Althobaiti, Bader B
AU  - Althobaiti BB
FAU - Allam, Hatem H
AU  - Allam HH
FAU - Elsayyad, Lamiaa K
AU  - Elsayyad LK
FAU - Shafie, Alaa
AU  - Shafie A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Albumins
MH  - Biomarkers
MH  - Calcium
MH  - Creatinine
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies/diagnosis
MH  - Female
MH  - Humans
MH  - Hypoxia
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*blood
MH  - Male
MH  - Parathyroid Hormone
MH  - Tumor Necrosis Factor-alpha
MH  - Vitamin D
MH  - *Vitamin D Deficiency/complications/diagnosis
MH  - Vitamins
EDAT- 2022/04/22 06:00
MHDA- 2022/04/23 06:00
CRDT- 2022/04/21 04:48
PHST- 2022/04/21 04:48 [entrez]
PHST- 2022/04/22 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
AID - 10.7754/Clin.Lab.2021.210540 [doi]
PST - ppublish
SO  - Clin Lab. 2022 Apr 1;68(4). doi: 10.7754/Clin.Lab.2021.210540.