PMID- 35444213
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Apr 20
TI  - Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age.
PG  - 6517
LID - 10.1038/s41598-022-10501-8 [doi]
LID - 6517
AB  - Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS 
      have been phased out of production in most developed countries and emerging PFAS 
      (short-chain PFAS and polyfluorinated compounds) are used as legacy PFAS 
      alternatives. The effect of legacy and emerging PFAS on cytokine homeostasis in 
      human remains poorly understood. This study aimed to evaluate the associations 
      between legacy and emerging PFAS and cytokine profiles, and identify the main 
      contributors to the disturbance of cytokine homeostasis. We quantified 21 PFAS in 
      198 Chinese women of childbearing age from 2015 to 2016. 13 cytokines were 
      measured using the Meso Scale Discovery U-PLEX and V-PLEX platforms. The 
      associations between PFAS exposure and cytokine levels were assessed using 
      multiple linear regression (single-exposure), and Bayesian kernel machine 
      regression (BKMR) models (PFAS mixture exposure). In single PFAS models, legacy 
      and alternative PFAS were positively associated with Th1 and Treg cytokines, and 
      negatively associated with Th2 and Th17 cytokines. For instance, each ln-unit 
      increase in 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA), 
      perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) was 
      associated with a decrease in IL-10 by - 0.228 (95% CI: - 0.336, - 0.120), 
      - 0.153 (95% CI: - 0.277, - 0.030), and - 0.174 (95% CI: - 0.339, - 0.010), 
      respectively. The BKMR model showed a significantly positive association of PFAS 
      mixture with TGF-beta and a negative association with IL-10. Overall, these results 
      indicate that both legacy and emerging PFAS may affect the homeostasis of 
      cytokines.
CI  - (c) 2022. The Author(s).
FAU - Nian, Min
AU  - Nian M
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong 
      University, Jinan, 250012, Shandong, China.
AD  - Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong 
      University, Jinan, 250012, Shandong, China.
FAU - Feng, Yan
AU  - Feng Y
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, No.1665, 
      Kongjiang Road, Shanghai, 200092, China.
AD  - The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200011, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, No.1665, 
      Kongjiang Road, Shanghai, 200092, China. chenqian911@126.com.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China. junjimzhang@sina.com.
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, No.1665, 
      Kongjiang Road, Shanghai, 200092, China. junjimzhang@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220420
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Cytokines)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Bayes Theorem
MH  - Cytokines
MH  - *Environmental Pollutants
MH  - Female
MH  - *Fluorocarbons/analysis
MH  - Homeostasis
MH  - Humans
MH  - Interleukin-10
PMC - PMC9021217
COIS- The authors declare no competing interests.
EDAT- 2022/04/22 06:00
MHDA- 2022/04/23 06:00
PMCR- 2022/04/20
CRDT- 2022/04/21 05:26
PHST- 2021/12/30 00:00 [received]
PHST- 2022/04/04 00:00 [accepted]
PHST- 2022/04/21 05:26 [entrez]
PHST- 2022/04/22 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2022/04/20 00:00 [pmc-release]
AID - 10.1038/s41598-022-10501-8 [pii]
AID - 10501 [pii]
AID - 10.1038/s41598-022-10501-8 [doi]
PST - epublish
SO  - Sci Rep. 2022 Apr 20;12(1):6517. doi: 10.1038/s41598-022-10501-8.