PMID- 35447156
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20230902
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 212
IP  - Pt B
DP  - 2022 Sep
TI  - Plasma concentrations of lipophilic persistent organic pollutants and glucose 
      homeostasis in youth populations.
PG  - 113296
LID - S0013-9351(22)00623-5 [pii]
LID - 10.1016/j.envres.2022.113296 [doi]
AB  - BACKGROUND: Exposure to lipophilic persistent organic pollutants (POPs) is 
      ubiquitous. POPs are metabolic disrupting chemicals and are potentially 
      diabetogenic. METHODS: Using a multi-cohort study including overweight 
      adolescents from the Study of Latino Adolescents at Risk (SOLAR, N = 301, 
      2001-2012) and young adults from the Southern California Children's Health Study 
      (CHS, N = 135, 2014-2018), we examined associations of POPs and risk factors for 
      type 2 diabetes. SOLAR participants underwent annual visits for a median of 2.2 
      years and CHS participants performed a single visit, during which a 2-h oral 
      glucose tolerance test was performed. Linear mixed models were used to examine 
      associations between plasma concentrations of POPs 
      [4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE), hexachlorobenzene (HCB), 
      PCBs-153, 138, 118, 180 and PBDEs-154, 153, 100, 85, 47] and changes in glucose 
      homeostasis across age and pubertal stage. RESULTS: In SOLAR, exposure to HCB, 
      PCB-118, and PBDE-153 was associated with dysregulated glucose metabolism. For 
      example, each two-fold increase in HCB was associated with approximately 2 mg/dL 
      higher glucose concentrations at 30 min (p = 0.001), 45 min (p = 0.0006), and 
      60 min (p = 0.03) post glucose challenge. Compared to individuals with low levels 
      of PCB-118, individuals with high levels exhibited a 4.7 mg/dL (p = 0.02) higher 
      glucose concentration at 15 min and a 3.6 mg/dL (p = 0.01) higher glucose 
      concentration at 30 min. The effects observed with exposure to organochlorine 
      compounds were independent of pubertal stages. PBDE-153 was associated with the 
      development of dysregulated glucose metabolism beginning in late puberty. At 
      Tanner stage 4, exposure to PBDE-153 was associated with a 12.7 mg/dL higher 
      60-min glucose concentration (p = 0.009) and a 16.1 mg*dl(-1)*hr(-1) higher 
      glucose AUC (p = 0.01). These associations persisted at Tanner 5. In CHS, 
      PBDE-153 and total PBDE were associated with similar increases in glucose 
      concentrations. CONCLUSION: Our results suggest that childhood exposure to 
      lipophilic POPs is associated with dysregulated glucose metabolism.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Baumert, Brittney O
AU  - Baumert BO
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States. Electronic address: bbaumert@usc.edu.
FAU - Goodrich, Jesse A
AU  - Goodrich JA
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
FAU - Hu, Xin
AU  - Hu X
AD  - Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and 
      Sleep Medicine, Emory University, Atlanta, GA, United States.
FAU - Walker, Douglas I
AU  - Walker DI
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, United States.
FAU - Alderete, Tanya L
AU  - Alderete TL
AD  - Department of Integrative Physiology, University of Colorado Boulder, Boulder, 
      CO, United States.
FAU - Chen, Zhanghua
AU  - Chen Z
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
FAU - Valvi, Damaskini
AU  - Valvi D
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, United States.
FAU - Rock, Sarah
AU  - Rock S
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
FAU - Berhane, Kiros
AU  - Berhane K
AD  - Department of Biostatistics, Columbia University, New York, NY, United States.
FAU - Gilliland, Frank D
AU  - Gilliland FD
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
FAU - Goran, Michael I
AU  - Goran MI
AD  - Department of Pediatrics, Children's Hospital of Los Angeles, The Saban Research 
      Institute, United States.
FAU - Jones, Dean P
AU  - Jones DP
AD  - Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and 
      Sleep Medicine, Emory University, Atlanta, GA, United States.
FAU - Conti, David V
AU  - Conti DV
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
FAU - Chatzi, Leda
AU  - Chatzi L
AD  - Department of Preventative Medicine, University of Southern California, Los 
      Angeles, CA, United States.
LA  - eng
GR  - U2C ES030163/ES/NIEHS NIH HHS/United States
GR  - R21 ES029681/ES/NIEHS NIH HHS/United States
GR  - P01 ES022845/ES/NIEHS NIH HHS/United States
GR  - R01 ES030691/ES/NIEHS NIH HHS/United States
GR  - R01 DK059211/DK/NIDDK NIH HHS/United States
GR  - R21 ES028903/ES/NIEHS NIH HHS/United States
GR  - R21 ES029328/ES/NIEHS NIH HHS/United States
GR  - R00 ES027870/ES/NIEHS NIH HHS/United States
GR  - R01 ES030364/ES/NIEHS NIH HHS/United States
GR  - T32 ES013678/ES/NIEHS NIH HHS/United States
GR  - P30 ES019776/ES/NIEHS NIH HHS/United States
GR  - R24 ES029490/ES/NIEHS NIH HHS/United States
GR  - K12 ES033594/ES/NIEHS NIH HHS/United States
GR  - R21 ES031824/ES/NIEHS NIH HHS/United States
GR  - R01 ES029944/ES/NIEHS NIH HHS/United States
GR  - P30 ES007048/ES/NIEHS NIH HHS/United States
GR  - P30 ES023515/ES/NIEHS NIH HHS/United States
GR  - R01 ES032189/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20220418
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Dichlorodiphenyl Dichloroethylene
MH  - *Environmental Pollutants
MH  - Glucose
MH  - Hexachlorobenzene
MH  - Homeostasis
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/toxicity
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
MH  - Young Adult
PMC - PMC9831292
MID - NIHMS1854160
OTO - NOTNLM
OT  - Flame retardants
OT  - Obesogens
OT  - Organochlorines
OT  - Pesticides
OT  - Polybrominated compounds
OT  - Type II diabetes
COIS- Conflict of interest disclosures. The authors declare that they have no conflicts 
      of interest. Declaration of competing financial interests. The authors declare 
      they have no actual or potential competing financial interests. Declaration of 
      interests ☒ The authors declare that they have no known competing financial 
      interests or personal relationships that could have appeared to influence the 
      work reported in this paper.
EDAT- 2022/04/22 06:00
MHDA- 2022/06/22 06:00
PMCR- 2023/09/01
CRDT- 2022/04/21 20:11
PHST- 2021/11/29 00:00 [received]
PHST- 2022/03/15 00:00 [revised]
PHST- 2022/04/09 00:00 [accepted]
PHST- 2022/04/22 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/04/21 20:11 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - S0013-9351(22)00623-5 [pii]
AID - 10.1016/j.envres.2022.113296 [doi]
PST - ppublish
SO  - Environ Res. 2022 Sep;212(Pt B):113296. doi: 10.1016/j.envres.2022.113296. Epub 
      2022 Apr 18.