PMID- 35448141
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2310-2861 (Electronic)
IS  - 2310-2861 (Linking)
VI  - 8
IP  - 4
DP  - 2022 Apr 13
TI  - Chitosan-Based Polyelectrolyte Complex Cryogels with Elasticity, Toughness and 
      Delivery of Curcumin Engineered by Polyions Pair and Cryostructuration Steps.
LID - 10.3390/gels8040240 [doi]
LID - 240
AB  - Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical 
      cross-linking. A much more friendly approach to deliver drugs in a controlled 
      manner is represented by polyelectrolyte complexes (PECs) physically stabilized 
      by spontaneous interactions between CS and natural or synthetic biocompatible 
      polyanions. PECs with tunable structures, morphologies, and mechanical properties 
      were fabricated in this paper by an innovative and sustainable strategy. 
      Carboxymethyl cellulose (CMC) or poly(2-acrylamido-2-methylpropanesulfonate 
      sodium salt) were used as aqueous solutions, while CS microparticles were evenly 
      dispersed in the polyanion solution, at pH 6.5, where CS was not soluble. 
      Cryostructuration of the dispersion in two steps (5 min at -196  degrees C, and 24 h at 
      -18  degrees C), and freeze-drying at -55  degrees C, 48 h, conducted to pre-PEC cryogels. Next 
      step was rearrangement of complementary polyions and the complex formation inside 
      the pore walls of cryogels by exposure of the pre-PECs at a source of H(+). PEC 
      cryogels with impressive elasticity and toughness were engineered in this study 
      by multiple-cryostructuration steps using CMC as polyanion with a molar mass of 
      250 kDa and an optimum concentration of polyanion and polycation. The 
      performances of PEC cryogels in sustained delivery of anti-inflammatory drugs 
      such as curcumin were demonstrated.
FAU - Dragan, Ecaterina Stela
AU  - Dragan ES
AUID- ORCID: 0000-0003-3656-6754
AD  - Department of Functional Polymers, "Petru Poni" Institute of Macromolecular 
      Chemistry, 700487 Iasi, Romania.
FAU - Dinu, Maria Valentina
AU  - Dinu MV
AUID- ORCID: 0000-0001-6627-8679
AD  - Department of Functional Polymers, "Petru Poni" Institute of Macromolecular 
      Chemistry, 700487 Iasi, Romania.
FAU - Ghiorghita, Claudiu Augustin
AU  - Ghiorghita CA
AD  - Department of Functional Polymers, "Petru Poni" Institute of Macromolecular 
      Chemistry, 700487 Iasi, Romania.
LA  - eng
PT  - Journal Article
DEP - 20220413
PL  - Switzerland
TA  - Gels
JT  - Gels (Basel, Switzerland)
JID - 101696925
PMC - PMC9024878
OTO - NOTNLM
OT  - carboxymethyl cellulose
OT  - chitosan
OT  - curcumin
OT  - drug delivery
OT  - poly(2-acrylamido-2-methyl-propansulfonic acid)
OT  - polyelectrolyte complex
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/22 06:00
MHDA- 2022/04/22 06:01
PMCR- 2022/04/13
CRDT- 2022/04/21 20:19
PHST- 2022/03/30 00:00 [received]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/04/12 00:00 [accepted]
PHST- 2022/04/21 20:19 [entrez]
PHST- 2022/04/22 06:00 [pubmed]
PHST- 2022/04/22 06:01 [medline]
PHST- 2022/04/13 00:00 [pmc-release]
AID - gels8040240 [pii]
AID - gels-08-00240 [pii]
AID - 10.3390/gels8040240 [doi]
PST - epublish
SO  - Gels. 2022 Apr 13;8(4):240. doi: 10.3390/gels8040240.