PMID- 35450844
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220614
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 50
IP  - 3
DP  - 2022 Apr
TI  - Vitamin D Deficiency and Relation to the New York Heart Association Functional 
      Class in Chronic Heart Failure.
PG  - 202-208
LID - 10.5543/tkda.2022.21024 [doi]
AB  - OBJECTIVE: Heart failure is an important mortality and morbidity. In this study, 
      we aimed to investigate the frequency of vitamin D deficiency in chronic heart 
      failure patients who live in a sunny region and to evaluate its relationship with 
      the New York Heart Association (NYHA) functional classes. METHODS: The study 
      included 657 patients. Demographic clinical, and laboratory parameters were 
      evaluated according to the NYHA classes. Ordinal regression analysis was used to 
      determine the parameters defining the NYHA class. RESULTS: The median serum 
      25-hydroxy-vitamin D [25(OH)D] level of study population was 16.88 ng/mL. It was 
      30 ng/mL. 25(OH)D level was positively correlated with eGFR, calcium, albumin, 
      hemoglobin, transferrin saturation, serum iron, while a negative correlation was 
      found with heart rate, parathormon, NT-proBNP, and CRP. Together with dereased ss 
      blocker use, increase in N-terminal pro-brain natriuretic peptide levels and left 
      atrial diameter, a decrease in vitamin D level (OR: 0.970, 95% CI: 0.945-0996, 
      P=.024) was independently associated with an increase in the New York Heart 
      Association class. CONCLUSION: Vitamin D deficiency and insufficiency are common 
      in patients with chronic heart failure, and vitamin D level is an important 
      determinant of the NYHA functional class in patients with heart failure.
FAU - Yilmaz Oztekin, Gulsum Meral
AU  - Yilmaz Oztekin GM
AD  - Department of Cardiology, University of Health Sciences, Antalya Training and 
      Research Hospital, Antalya, Turkey.
FAU - Genc, Ahmet
AU  - Genc A
AD  - Department of Cardiology, University of Health Sciences, Antalya Training and 
      Research Hospital, Antalya, Turkey.
FAU - Arslan, Sakir
AU  - Arslan S
AD  - Department of Cardiology, University of Health Sciences, Antalya Training and 
      Research Hospital, Antalya, Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Biomarkers
MH  - Chronic Disease
MH  - *Heart Failure/complications/epidemiology
MH  - Humans
MH  - Natriuretic Peptide, Brain
MH  - New York
MH  - Peptide Fragments
MH  - Vitamin D
MH  - *Vitamin D Deficiency/complications/epidemiology
EDAT- 2022/04/23 06:00
MHDA- 2022/04/26 06:00
CRDT- 2022/04/22 07:04
PHST- 2022/04/22 07:04 [entrez]
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
AID - 10.5543/tkda.2022.21024 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2022 Apr;50(3):202-208. doi: 10.5543/tkda.2022.21024.