PMID- 35451183
OWN - NLM
STAT- MEDLINE
DCOM- 20220520
LR  - 20220629
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 18
IP  - 20
DP  - 2022 May
TI  - 2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study.
PG  - e2107652
LID - 10.1002/smll.202107652 [doi]
AB  - Human health can be affected by materials indirectly through exposure to the 
      environment or directly through close contact and uptake. With the ever-growing 
      use of 2D materials in many applications such as electronics, medical 
      therapeutics, molecular sensing, and energy storage, it has become more pertinent 
      to investigate their impact on the immune system. Dendritic cells (DCs) are 
      highly important, considering their role as the main link between the innate and 
      the adaptive immune system. By using primary human DCs, it is shown that 
      hexagonal boron nitride (hBN), graphene oxide (GO) and molybdenum disulphide have 
      minimal effects on viability. In particular, it is evidenced that hBN and GO 
      increase DC maturation, while GO leads to the release of reactive oxygen species 
      and pro-inflammatory cytokines. hBN and MoS(2) increase T cell proliferation with 
      and without the presence of DCs. hBN in particular does not show any sign of 
      downstream T cell polarization. The study allows ranking of the three materials 
      in terms of inherent toxicity, providing the following trend: GO > hBN  approximately  MoS(2) , 
      with GO the most cytotoxic.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Lin, Hazel
AU  - Lin H
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Peng, Shiyuan
AU  - Peng S
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Guo, Shi
AU  - Guo S
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Ma, Baojin
AU  - Ma B
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Lucherelli, Matteo Andrea
AU  - Lucherelli MA
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Royer, Cathy
AU  - Royer C
AD  - Plateforme Imagerie In Vitro de l'ITI Neurostra, CNRS UAR 3156, University of 
      Strasbourg, Strasbourg, 67000, France.
FAU - Ippolito, Stefano
AU  - Ippolito S
AD  - CNRS, ISIS, Universite de Strasbourg, Strasbourg, 67000, France.
FAU - Samori, Paolo
AU  - Samori P
AD  - CNRS, ISIS, Universite de Strasbourg, Strasbourg, 67000, France.
FAU - Bianco, Alberto
AU  - Bianco A
AUID- ORCID: 0000-0002-1090-296X
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220421
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 81AH48963U (Molybdenum)
SB  - IM
MH  - *Dendritic Cells
MH  - Humans
MH  - *Molybdenum/toxicity
OTO - NOTNLM
OT  - boron nitride
OT  - cytokines
OT  - graphene
OT  - immune system
OT  - molybdenum disulphide
OT  - toxicity
EDAT- 2022/04/23 06:00
MHDA- 2022/05/21 06:00
CRDT- 2022/04/22 07:06
PHST- 2022/03/24 00:00 [revised]
PHST- 2021/12/09 00:00 [received]
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/05/21 06:00 [medline]
PHST- 2022/04/22 07:06 [entrez]
AID - 10.1002/smll.202107652 [doi]
PST - ppublish
SO  - Small. 2022 May;18(20):e2107652. doi: 10.1002/smll.202107652. Epub 2022 Apr 21.