PMID- 35451624
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20220926
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 33
IP  - 8
DP  - 2022 Aug
TI  - Associations between bone mineral density and subclinical peripheral arterial 
      disease in elderly men with type 2 diabetes mellitus.
PG  - 1715-1724
LID - 10.1007/s00198-022-06404-z [doi]
AB  - The association between peripheral arterial disease (PAD) and osteoporosis in 
      elderly men with type 2 diabetes mellitus (T2DM) remains unclear. We demonstrated 
      the association between subclinical PAD and decreased total hip bone mineral 
      density (BMD) in men aged >/= 55 years with T2DM, providing clinical clues for the 
      early detection of decreased bone density in total hip. PURPOSE: To investigate 
      the association between subclinical peripheral arterial disease (PAD) and bone 
      mineral density (BMD) at total hip, femoral neck, and lumbar spine (L(1-4)) in 
      elderly men with type 2 diabetes mellitus (T2DM). METHODS: We identified 2,466 
      patients with confirmed diabetes in this retrospective cross-sectional study. A 
      total of 272 men aged >/= 55 years with T2DM (50 with subclinical PAD and 222 
      without PAD) were analyzed. Partial correlation analysis was conducted to explore 
      the associations between ankle-brachial index (ABI) and BMD. Multivariate 
      logistic regression analysis was performed to analyze the contributor for low 
      bone density (T-score <  - 1.0). RESULTS: Patients with T2DM and subclinical PAD 
      (ABI </= 0.9) had significantly lower total hip BMD and T-score (BMD, 0.87 +/- 0.14 
      vs. 0.92 +/- 0.15 g/cm(2), P = 0.014; T-score, -1.30 [-1.70 to -0.45] vs. -0.80 
      [-1.40 to 0.00], P = 0.009) than those in the control group. The partial 
      correlation analyses indicated that ABI significantly correlated with the total 
      hip T-score (adjusted r = 0.166, P = 0.009). The logistic regression analysis 
      indicated that subclinical PAD was an independent risk factor for the risk of 
      decreased bone density in total hip (adjusted odds ratio [95% CI]: 8.933 
      [1.075-74.222], P = 0.043).  CONCLUSION: Subclinical PAD (ABI </= 0.9) could be 
      used as a risk factor for decreased total hip BMD in men aged >/= 55 years with 
      T2DM, which provides clinical clues for the early detection of low bone density 
      in total hip in such populations.
CI  - (c) 2022. International Osteoporosis Foundation and National Osteoporosis 
      Foundation.
FAU - Zhang, X
AU  - Zhang X
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Xu, Y
AU  - Xu Y
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Li, F
AU  - Li F
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Chen, M
AU  - Chen M
AUID- ORCID: 0000-0003-0639-180X
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. 
      173363733@qq.com.
LA  - eng
GR  - Y20210432/Wenzhou Municipal Science and Technology Bureau/
PT  - Journal Article
DEP - 20220422
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Aged
MH  - Bone Density
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - Male
MH  - *Osteoporosis/complications
MH  - *Peripheral Arterial Disease/complications
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Ankle-brachial index
OT  - Bone mineral density
OT  - Elderly men
OT  - Subclinical peripheral arterial disease
OT  - T-scores
OT  - Type 2 diabetes mellitus
EDAT- 2022/04/23 06:00
MHDA- 2022/09/28 06:00
CRDT- 2022/04/22 12:02
PHST- 2021/08/25 00:00 [received]
PHST- 2022/04/12 00:00 [accepted]
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/04/22 12:02 [entrez]
AID - 10.1007/s00198-022-06404-z [pii]
AID - 10.1007/s00198-022-06404-z [doi]
PST - ppublish
SO  - Osteoporos Int. 2022 Aug;33(8):1715-1724. doi: 10.1007/s00198-022-06404-z. Epub 
      2022 Apr 22.