PMID- 35452357
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20230207
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Print)
IS  - 2164-5515 (Linking)
VI  - 18
IP  - 5
DP  - 2022 Nov 30
TI  - Self-Reported adverse events among Chinese healthcare workers immunized with 
      COVID-19 vaccines composed of inactivated SARS-CoV-2.
PG  - 2064134
LID - 10.1080/21645515.2022.2064134 [doi]
LID - 2064134
AB  - Mass vaccination is critical to control the pandemic of coronavirus disease 2019 
      (COVID-19). Fear of adverse events (AEs) after COVID-19 vaccination is a main 
      factor associated with vaccination hesitancy. We aimed to analyze AEs in 
      healthcare workers (HCWs) vaccinated with COVID-19 vaccines (Aikewei or 
      CoronaVac) composed of inactivated virus. We used a structured self-administered 
      questionnaire to conduct two surveys on COVID-19 vaccination among HCWs in 
      perinatal medicine and obstetrics/gynecology from April 5 to April 21, 2021. In 
      total, 1392 HCWs who had received at least one vaccine dose were included. Of 
      them, 1264 (90.8%) were females and 1047 (75.2%) received two doses. The overall 
      incidence of any AEs after the first and second dose was 38.2% (532/1392) and 
      31.0% (325/1047) respectively (chi2 = 13.506, P = .0002). Female and HCWs aged 
      18-30 y were more likely to report AEs. The most common AEs were local reaction, 
      accounting for 48.1% and 67.4% of all AEs after the first and second dose 
      respectively. The systemic AEs were mainly neurological (9.8% and 4.8% after the 
      first and second injection respectively) and flu-like symptoms (6.3% and 3.2%). 
      Overall, most of AEs were mild, only 5.1% (after the first dose) and 2.8% (after 
      the second dose) of individuals with AEs received symptomatic treatment or sick 
      leaves, and none of them required hospitalization. Our data added more evidence 
      that inactivated COVID-19 vaccines are highly safe. The data are valuable to 
      overcome vaccine hesitancy associated with concerns about the safety of COVID-19 
      vaccines.
FAU - Cheng, Yandong
AU  - Cheng Y
AD  - Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Li, Taishun
AU  - Li T
AD  - Department of Biomedicine Statistics, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Zheng, Yaning
AU  - Zheng Y
AD  - Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Xu, Biyun
AU  - Xu B
AD  - Department of Biomedicine Statistics, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Bi, Yan
AU  - Bi Y
AUID- ORCID: 0000-0002-8485-6820
AD  - Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Hu, Yali
AU  - Hu Y
AD  - Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Zhou, Yi-Hua
AU  - Zhou YH
AUID- ORCID: 0000-0001-8880-0392
AD  - Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220422
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Vaccines, Inactivated)
SB  - IM
CIN - Hum Vaccin Immunother. 2022 Nov 30;18(5):2090178. PMID: 35736565
CIN - Hum Vaccin Immunother. 2022 Aug 5;:2099163. PMID: 35930374
MH  - *COVID-19/prevention & control
MH  - *COVID-19 Vaccines/adverse effects
MH  - China/epidemiology
MH  - Female
MH  - *Health Personnel
MH  - Humans
MH  - Male
MH  - SARS-CoV-2
MH  - Self Report
MH  - Vaccination/adverse effects
MH  - Vaccines, Inactivated/adverse effects
PMC - PMC9897645
OTO - NOTNLM
OT  - COVID-19
OT  - adverse events
OT  - healthcare workers
OT  - inactivated SARS-CoV-2
OT  - vaccination
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2022/04/23 06:00
MHDA- 2022/07/08 06:00
PMCR- 2022/04/22
CRDT- 2022/04/22 17:11
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/04/22 17:11 [entrez]
PHST- 2022/04/22 00:00 [pmc-release]
AID - 2064134 [pii]
AID - 10.1080/21645515.2022.2064134 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2022 Nov 30;18(5):2064134. doi: 
      10.1080/21645515.2022.2064134. Epub 2022 Apr 22.