PMID- 35452408
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220822
IS  - 1943-2704 (Electronic)
IS  - 1044-7946 (Linking)
VI  - 34
IP  - 4
DP  - 2022 Apr
TI  - Performance of biodegradable temporizing matrix vs collagen-chondroitin silicone 
      bilayer dermal regeneration substitutes in soft tissue wound healing: a 
      retrospective analysis.
PG  - 106-115
LID - 10.25270/wnds/2022.106115 [doi]
AB  - INTRODUCTION: This study compared outcomes of soft tissue reconstruction using 
      biodegradable temporizing matrix (BTM) and collagen-chondroitin silicone (CCS) 
      skin substitutes. OBJECTIVE: In this study, the authors compared wound healing 
      rates and complication rates between BTM and CCS. MATERIALS AND METHODS: This 
      retrospective study reviewed outcomes for adult patients who underwent soft 
      tissue reconstruction with either BTM or CCS skin substitutes between 2015 and 
      2020. Demographics, wound characteristics, surgical details, and complications 
      were recorded. RESULTS: Ninety-seven patients were included, of whom 51 (52.6%) 
      were treated with BTM graft and 46 (47.4%) with CCS bilayer graft. The mean 
      patient age was 48.2 years (range, 18-93 years). Wound etiologies included burn, 
      trauma, iatrogenic, compartment syndrome, skin cancer, and osteomyelitis. The 
      median template size was 147 cm2 and 100 cm2 for BTM and CCS, respectively (P 
      =.337). Skin grafts were applied to 39 patients (84.8%) treated with CCS compared 
      with 28 (54.9%) treated with BTM (P =.006); the remaining wounds healing 
      secondarily. The template-related and skin graft-related complications of 
      infection, dehiscence, and hematoma or seroma were comparable between groups. The 
      rate of skin graft failure was significantly higher in the CCS cohort (n = 9 
      [23.1%]) compared with the BTM group (n = 1 [3.6%]) (P =.006). More secondary 
      procedures were required after CCS placement (mean +/- standard deviation, 1.9 +/- 
      1.8; range, 0-9) than after BTM (mean, 1.0 +/- 0.9; range 0-4) (P =.002). There was 
      no statistical significance in the frequency of definitive closure between BTM 
      and CCS (n = 31 [60.8%] vs n = 28 [60.9%], respectively; P =.655). CONCLUSIONS: 
      Compared with CCS, BTM had comparable closure and complication rates and required 
      fewer secondary procedures and/or subsequent skin grafting.
FAU - Wu, Shannon S
AU  - Wu SS
AD  - Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 
      Cleveland, Ohio.
FAU - Wells, Michael
AU  - Wells M
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio.
FAU - Ascha, Mona
AU  - Ascha M
AD  - Division of Plastic Surgery, Department of Surgery, MetroHealth Medical Center, 
      Cleveland, Ohio.
FAU - Gatherwright, James
AU  - Gatherwright J
AD  - Division of Plastic Surgery, Department of Surgery, MetroHealth Medical Center, 
      Cleveland, Ohio.
FAU - Chepla, Kyle
AU  - Chepla K
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Wounds
JT  - Wounds : a compendium of clinical research and practice
JID - 9010276
RN  - 0 (Silicones)
RN  - 9007-27-6 (Chondroitin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chondroitin
MH  - Collagen/therapeutic use
MH  - Humans
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Silicones
MH  - Skin Transplantation/methods
MH  - *Skin, Artificial
MH  - *Soft Tissue Injuries
MH  - Wound Healing
MH  - Young Adult
EDAT- 2022/04/23 06:00
MHDA- 2022/04/27 06:00
CRDT- 2022/04/22 17:11
PHST- 2022/04/22 17:11 [entrez]
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
AID - 10.25270/wnds/2022.106115 [doi]
PST - ppublish
SO  - Wounds. 2022 Apr;34(4):106-115. doi: 10.25270/wnds/2022.106115.