PMID- 35452416
OWN - NLM
STAT- MEDLINE
DCOM- 20220606
LR  - 20220606
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 28
IP  - 4
DP  - 2022 May
TI  - Serum Cat S, TSP-1, IL-11, BNP and sST2 Diagnostic and Prognostic Value in 
      Chronic Heart Failure.
PG  - 55-59
LID - AT7396 [pii]
AB  - CONTEXT: Objectives * This study aimed to assess the diagnostic value of serum 
      brain natriuretic peptide (BNP), cathepsin S (Cat S), serum soluble ST2 receptor 
      (sST2), platelet reactive protein-1 (TSP-1) and interleukin-11 (IL-11) in 
      patients with chronic heart failure (CHF). CONTEXT: Materials and Methods * A 
      total of 112 patients admitted to in our hospital with HF were enrolled as the HF 
      group and 120 healthy people undergoing physical examination were assigned to the 
      control group. The serum levels of Cat S, TSP-1, IL-11, sST2 and BNP were 
      measured and compared in the subgroups categorized according to New York Heart 
      Association (NYHA) Functional Classification. Pearson correlation was applied to 
      analyze the correlation between serum Cat S, TSP-1, IL-11, sST2 and BNP and NYHA 
      functional class. Moreover, multivariate logistic regression was used to analyze 
      the HF influencing factors. CONTEXT: Results * No correlation was found between 
      the 2 groups in terms of general information, such as age, gender, body mass 
      index (BMI), systolic blood pressure, diastolic blood pressure, smoking and heart 
      rate (P > .05). The left ventricular ejection fraction (LVEF) in the HF group was 
      lower than in the control group, while the level of LV end diastolic dimension 
      (LVEDD) and left ventricular end diastolic volume (LVEDV) was significantly 
      higher (P < .05). The levels of Cat S, TSP-1, sST2, IL-11 and BNP in the HF group 
      were higher than in the control group (P < .05). The levels of Cat S, TSP-1, 
      sST2, IL-11 and BNP in the grade IV group were higher than those in the grade II 
      and III groups (P < .05). Serum Cat S, TSP-1, IL-11, sST2 and BNP levels were 
      positively correlated with NYHA functional class (R = 0.568, 0.409, 0.472, 0.547, 
      0.632, respectively) (P < .001). Multivariate logistic regression analysis 
      demonstrated that LVEF, LVEDD, LVEDV, Cat S, TSP-1, IL-11, sST2 and BNP were 
      independent markers of CHF. CONTEXT: Conclusion * Abnormal Cat S, TSP-1, IL-11, 
      sST2 and BNP levels were found in patients with CHF, and were highly associated 
      with the cardiac function grades of CHF. Therefore, serum Cat S, TSP-1, IL-11, 
      sST2 and BNP levels can serve as independent markers for CHF.
FAU - Xiang, Yang
AU  - Xiang Y
FAU - Zhang, Zhixin
AU  - Zhang Z
FAU - Xie, Cui
AU  - Xie C
FAU - Wang, Lin
AU  - Wang L
FAU - Wu, You
AU  - Wu Y
FAU - Zhan, Yu
AU  - Zhan Y
FAU - Chen, Dan
AU  - Chen D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-11)
RN  - 0 (Thrombospondin 1)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.22.27 (cathepsin S)
SB  - IM
MH  - Biomarkers
MH  - Cathepsins
MH  - Chronic Disease
MH  - *Heart Failure/diagnosis
MH  - Humans
MH  - Interleukin-11
MH  - *Natriuretic Peptide, Brain/analysis
MH  - Prognosis
MH  - Stroke Volume
MH  - Thrombospondin 1
MH  - Ventricular Function, Left
EDAT- 2022/04/23 06:00
MHDA- 2022/06/07 06:00
CRDT- 2022/04/22 17:11
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/04/22 17:11 [entrez]
AID - AT7396 [pii]
PST - ppublish
SO  - Altern Ther Health Med. 2022 May;28(4):55-59.