PMID- 35453042
OWN - NLM
STAT- MEDLINE
DCOM- 20220504
LR  - 20220701
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 130
DP  - 2022 May
TI  - Minimum clinically important difference (MCID) of the personal impact of epilepsy 
      scale (PIES).
PG  - 108691
LID - S1525-5050(22)00140-8 [pii]
LID - 10.1016/j.yebeh.2022.108691 [doi]
AB  - INTRODUCTION: The Personal Impact of Epilepsy Scale (PIES) assesses patient 
      functional status in subscales of (1) seizure impact, (2) medication effects, (3) 
      mood & social status, and (4) overall quality of life. This study was designed to 
      determine the Minimal Clinically Important Change (MCID) in PIES subscale and 
      total scores that demonstrate improvement. METHODS: To ascertain the 
      correspondence of PIES score change and clinical status change (improved, same, 
      worse) in each PIES subscale and total score, we used two distinct retrospective 
      anchor-based assessments of clinical status (patient self-assessment and trained 
      rater assessment) across two clinic visits. Mean PIES scores were compared 
      between clinical status groups, controlling for days between visits and initial 
      clinical status. Personal Impact of Epilepsy Scale score change was quantified 
      for each group to determine MCID. A small prospective proof-of-concept study was 
      conducted in a separate subject group. RESULTS: Patient self-report anchor 
      analysis demonstrated lower (better) PIES scores in the "improved" group vs the 
      "worse" group on the mood & social subscale (p < .001) and total score 
      (p = .002), with a similar trend on the seizure subscale (p = 0.056). Clinical 
      rater anchor analysis demonstrated lower PIES scores in the "improved" vs "worse" 
      group in the mood & social subscale (p = .029) and a trend in total score 
      (p = .082). For the "improved" group, the reduction in PIES scores between visits 
      averaged across both anchor analyses was 8.14% for subscales and 8.67% for total 
      score. DISCUSSION/CONCLUSION: Reduction of 8% on a PIES subscale or total score 
      indicates meaningful improvement in patient clinical status, and is designated 
      the MCID for this instrument. Personal Impact of Epilepsy Scale can be useful in 
      day-to-day clinical care and as an outcome metric in clinical research.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Martz, Gabriel
AU  - Martz G
AD  - Hartford HealthCare, 85 Seymour St, Hartford, CT 06102, United States; Norton 
      Neuroscience Institute, 4915 Norton Healthcare Blvd, Louisville, KY 40241, United 
      States. Electronic address: Gabriel.Martz@hhchealth.org.
FAU - Fisher, Robert S
AU  - Fisher RS
AD  - Stanford University School of Medicine, 213 Quarry Rd, Palo Alto, CA 94304, 
      United States. Electronic address: Robert.Fisher@Stanford.edu.
FAU - Folley, Bradley
AU  - Folley B
AD  - Norton Neuroscience Institute, 4915 Norton Healthcare Blvd, Louisville, KY 40241, 
      United States.
FAU - Panza, Gregory A
AU  - Panza GA
AD  - Hartford HealthCare, 85 Seymour St, Hartford, CT 06102, United States.
FAU - Ando, Fumika
AU  - Ando F
AD  - Hartford HealthCare, 85 Seymour St, Hartford, CT 06102, United States.
FAU - McEachern, Corey
AU  - McEachern C
AD  - Norton Neuroscience Institute, 4915 Norton Healthcare Blvd, Louisville, KY 40241, 
      United States.
FAU - Blinn, Alma
AU  - Blinn A
AD  - Norton Neuroscience Institute, 4915 Norton Healthcare Blvd, Louisville, KY 40241, 
      United States.
FAU - Cramer, Joyce A
AU  - Cramer JA
AD  - Consultant, 2207 Bancroft St., Houston, TX 77027, United States; Yale University 
      School of Medicine, 333 Cedar St, New Haven, CT 06510, United States. Electronic 
      address: Joyce.Cramer@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220419
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - *Epilepsy/diagnosis
MH  - Humans
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Seizures
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Epilepsy
OT  - Functional status
OT  - MCID
OT  - Quality of life
OT  - Seizures
EDAT- 2022/04/23 06:00
MHDA- 2022/05/06 06:00
CRDT- 2022/04/22 20:14
PHST- 2022/01/17 00:00 [received]
PHST- 2022/03/30 00:00 [revised]
PHST- 2022/03/30 00:00 [accepted]
PHST- 2022/04/23 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
PHST- 2022/04/22 20:14 [entrez]
AID - S1525-5050(22)00140-8 [pii]
AID - 10.1016/j.yebeh.2022.108691 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2022 May;130:108691. doi: 10.1016/j.yebeh.2022.108691. Epub 2022 
      Apr 19.