PMID- 35453849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Mar 24
TI  - Clinical and Laboratory Characteristics of Normal Weight and Obese Individuals 
      with Non-Alcoholic Fatty Liver Disease.
LID - 10.3390/diagnostics12040801 [doi]
LID - 801
AB  - Non-alcoholic fatty liver disease (NAFLD) has had, over the past few decades, a 
      progressively growing prevalence among the general population all over the world, 
      in parallel with metabolic conditions such as type 2 diabetes mellitus (T2DM), 
      dyslipidemia, and obesity. However, NAFLD is also detected in 10-13% of subjects 
      with a body mass index (BMI) </= 25 kg/m(2) (lean-NAFLD), whose major risk factors 
      remain unknown. In this study, we aimed to characterize the clinical features and 
      associated risk factors of lean-NAFLD in comparison with obese-NAFLD patients. 
      Consecutive patients diagnosed with NAFLD by vibration-controlled transient 
      elastography and controlled attenuation parameter were prospectively enrolled. 
      Biological and clinical data obtained from the participants were stratified 
      according to their BMI in two groups: lean-NAFLD and obese-NAFLD. In total, 331 
      patients (56.8% males) were included in the final analysis. Most of the subjects 
      were obese-NAFLD (n = 258, 77.9%) and had a higher prevalence of T2DM, 
      dyslipidemia, and components of the metabolic syndrome, together with abnormal 
      biological parameters. Regarding liver stiffness measurements, the proportion of 
      subjects with at least significant fibrosis (>/=F2) was approximately twofold 
      higher among obese-NAFLD (43.81%) in comparison with lean-NAFLD patients 
      (23.29%). Moreover, obese individuals had a higher risk for liver fibrosis (OR = 
      2.6, 95%, CI 1.5-4.42, p < 0.001) than lean individuals. Although associated 
      metabolic conditions and at least significant liver fibrosis were present in 
      approximately one-quarter of the patients, these were more frequent among 
      obese-NAFLD patients. Therefore, individualized screening strategies for NAFLD 
      should be established according to BMI.
FAU - Trifan, Anca
AU  - Trifan A
AUID- ORCID: 0000-0001-9144-5520
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Rotaru, Adrian
AU  - Rotaru A
AUID- ORCID: 0000-0002-6459-6996
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Stafie, Remus
AU  - Stafie R
AUID- ORCID: 0000-0003-1460-6559
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Stratina, Ermina
AU  - Stratina E
AUID- ORCID: 0000-0002-8526-988X
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Zenovia, Sebastian
AU  - Zenovia S
AUID- ORCID: 0000-0003-0441-3980
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Nastasa, Robert
AU  - Nastasa R
AUID- ORCID: 0000-0002-8678-0663
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Huiban, Laura
AU  - Huiban L
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Cuciureanu, Tudor
AU  - Cuciureanu T
AUID- ORCID: 0000-0003-1550-8870
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Muzica, Cristina
AU  - Muzica C
AUID- ORCID: 0000-0003-0891-5961
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Chiriac, Stefan
AU  - Chiriac S
AUID- ORCID: 0000-0003-2497-9236
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Girleanu, Irina
AU  - Girleanu I
AUID- ORCID: 0000-0001-5925-1232
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Singeap, Ana-Maria
AU  - Singeap AM
AUID- ORCID: 0000-0001-5621-548X
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Sfarti, Catalin
AU  - Sfarti C
AUID- ORCID: 0000-0001-7074-5938
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Cojocariu, Camelia
AU  - Cojocariu C
AUID- ORCID: 0000-0001-6395-335X
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
FAU - Stanciu, Carol
AU  - Stanciu C
AD  - Department of Gastroenterology, Grigore T. Popa University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Institute of Gastroenterology and Hepatology, "St. Spiridon" University Hospital, 
      700111 Iasi, Romania.
LA  - eng
PT  - Journal Article
DEP - 20220324
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9028454
OTO - NOTNLM
OT  - VCTE
OT  - lean
OT  - liver steatosis
OT  - liver stiffness
OT  - obese
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/24 06:01
PMCR- 2022/03/24
CRDT- 2022/04/23 01:02
PHST- 2022/02/23 00:00 [received]
PHST- 2022/03/23 00:00 [revised]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/04/23 01:02 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/24 06:01 [medline]
PHST- 2022/03/24 00:00 [pmc-release]
AID - diagnostics12040801 [pii]
AID - diagnostics-12-00801 [pii]
AID - 10.3390/diagnostics12040801 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Mar 24;12(4):801. doi: 10.3390/diagnostics12040801.