PMID- 35455727
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Apr 11
TI  - Change of Optical Coherence Tomography Morphology and Associated Structural 
      Outcome in Diabetic Macular Edema after Ranibizumab Treatment.
LID - 10.3390/jpm12040611 [doi]
LID - 611
AB  - (1) Background: To investigate the correlation between therapeutic outcome and 
      morphologic changes for diabetic macular edema (DME) after intravitreal injection 
      of ranibizumab (IVIR). (2) Methods: This retrospective study included 228 eyes 
      received IVIR for DME. Each participant was traced for two years after the 
      initial IVIR, while the data of ophthalmic examination, optical coherence 
      tomography (OCT) image, and systemic diseases were collected. The study 
      population was categorized into different subgroups according to the existence of 
      OCT morphologic change and the initial OCT morphologic pattern, including diffuse 
      retinal thickening (DRT), cystoid macular edema (CME), serous retinal detachment 
      (SRD), and vitreomacular interface abnormalities (VMIAs). The primary outcomes 
      were the baseline best-corrected visual acuity (BCVA) and central macular 
      thickness (CMT) during a two-year study period. The distribution of OCT 
      morphologic change and its relation to primary outcome were analyzed. (3) 
      Results: Comparing the 42 eyes (18.4%) with OCT morphological changes to another 
      186 eyes (81.6%) without such alteration, the former showed a poorer baseline 
      BCVA (0.84 +/- 0.39 vs. 0.71 +/- 0.36, p = 0.035), worse final BCVA (0.99 +/- 0.44 vs. 
      0.67 +/- 0.30, p = 0.001), and thicker final CMT (354.21 +/- 89.02 vs. 305.33 +/- 
      83.05, p = 0.001). Moreover, the VMIA developed in 14.9% of all DME patients 
      presenting the most common morphologic change among DRT, CME, and SRD. Besides, 
      the presence of stroke was independently correlated to the morphologic change 
      (adjusted odds ratio [aOR]: 6.381, 95% confidence interval (CI): 1.112-36.623, p 
      = 0.038). (4) Conclusions: The change of OCT morphology in DME patients receiving 
      IVIR was correlated to worse structural and visual outcome while the formation of 
      VMIA most commonly occurred after initial treatment.
FAU - Chen, Nan-Ni
AU  - Chen NN
AUID- ORCID: 0000-0002-1577-4012
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
FAU - Lai, Chien-Hsiung
AU  - Lai CH
AUID- ORCID: 0000-0001-8334-4156
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
AD  - Department of Nursing, Chang Gung University of Science and Technology, Chiayi 
      61363, Taiwan.
AD  - School of Traditional Chinese Medicine, College of Medicine, Chang Gung 
      University, Taoyuan 33302, Taiwan.
FAU - Lee, Chai-Yi
AU  - Lee CY
AUID- ORCID: 0000-0002-5719-0488
AD  - Department of Ophthalmology, Show Chwan Hospital, Changhua 50861, Taiwan.
FAU - Kuo, Chien-Neng
AU  - Kuo CN
AD  - Department of Ophthalmology, Changhua Christian Hospital, Changhua 50861, Taiwan.
FAU - Chen, Ching-Lung
AU  - Chen CL
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
AD  - Department of Optometry, Chung Hwa University of Medical Technology, Taipei 
      10650, Taiwan.
FAU - Huang, Jou-Chen
AU  - Huang JC
AD  - Department of Ophthalmology, Taipei Medical University Hospital, Taipei 110301, 
      Taiwan.
AD  - Department of Ophthalmology, School of Medicine, College of Medicine, Taipei 
      Medical University, Taipei 110301, Taiwan.
FAU - Wu, Pei-Chen
AU  - Wu PC
AD  - Department of Ophthalmology, Landseed International Hospital, Taoyuan 32449, 
      Taiwan.
FAU - Wu, Pei-Lun
AU  - Wu PL
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
FAU - Chen, Chau-Yin
AU  - Chen CY
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9027951
OTO - NOTNLM
OT  - antivascular endothelial growth factors
OT  - diabetic macular edema
OT  - optical coherence tomography
OT  - vitreomacular interface abnormality
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/24 06:01
PMCR- 2022/04/11
CRDT- 2022/04/23 01:07
PHST- 2022/03/26 00:00 [received]
PHST- 2022/04/08 00:00 [revised]
PHST- 2022/04/09 00:00 [accepted]
PHST- 2022/04/23 01:07 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/24 06:01 [medline]
PHST- 2022/04/11 00:00 [pmc-release]
AID - jpm12040611 [pii]
AID - jpm-12-00611 [pii]
AID - 10.3390/jpm12040611 [doi]
PST - epublish
SO  - J Pers Med. 2022 Apr 11;12(4):611. doi: 10.3390/jpm12040611.