PMID- 35455737
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Apr 12
TI  - Efficacy of Endoscopic and Surgical Treatments for Gastroesophageal Reflux 
      Disease: A Systematic Review and Network Meta-Analysis.
LID - 10.3390/jpm12040621 [doi]
LID - 621
AB  - Although various endoscopic and surgical procedures are available for the 
      treatment of gastroesophageal reflux disease (GERD), the comparative efficacy of 
      these treatments has not been fully elucidated. This study aimed to 
      comprehensively evaluate the efficacy of various endoscopic and surgical 
      treatments for GERD. All relevant randomized controlled trials published through 
      August 2021 that compared the efficacy of endoscopic and surgical GERD 
      treatments, including radiofrequency energy delivery, endoscopic plication, 
      reinforcement of the lower esophageal sphincter (LES), and surgical 
      fundoplication, were searched. A network meta-analysis was performed to analyze 
      treatment outcomes, including the requirement of proton pump inhibitor (PPI) 
      continuation and GERD-health-related quality of life questionnaire score 
      (GERD-HRQL). As such, 25 studies with 2854 patients were included in the 
      analysis. Endoscopic plication, reinforcement of the LES, and surgical 
      fundoplication were effective in reducing the requirement of PPI continuation 
      compared to PPI therapy (pooled risk ratio (RR) (95% confidence interval [CI]): 
      endoscopic plication, 0.34 (0.21-0.56); reinforcement of LES, 0.32 (0.16-0.63), 
      and surgical fundoplication, 0.16 (0.06-0.42)). Radiofrequency energy delivery 
      tended to reduce the requirement of PPI continuation compared to PPI therapy (RR 
      (95% CI): 0.55 (0.25-1.18)). In terms of GERD-HRQL, all endoscopic and surgical 
      treatments were superior to PPI therapy. In conclusion, all endoscopic or 
      surgical treatments, except radiofrequency energy delivery, were effective for 
      discontinuation of PPI medication, especially surgical fundoplication. Quality of 
      life, measured by GERD-HRQL, also improved in patients who underwent endoscopic 
      or surgical treatment compared to those who received PPI therapy.
FAU - Gong, Eun Jeong
AU  - Gong EJ
AUID- ORCID: 0000-0003-3996-3472
AD  - Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 
      24253, Korea.
FAU - Park, Chan Hyuk
AU  - Park CH
AUID- ORCID: 0000-0003-3824-3481
AD  - Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang 
      University College of Medicine, Guri 11923, Korea.
FAU - Jung, Da Hyun
AU  - Jung DH
AD  - Division of Gastroenterology, Department of Internal Medicine, Severance 
      Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
FAU - Kang, Sun Hyung
AU  - Kang SH
AUID- ORCID: 0000-0002-1913-4346
AD  - Department of Internal Medicine, Chungnam National University School of Medicine, 
      Daejeon 35015, Korea.
FAU - Lee, Ju Yup
AU  - Lee JY
AUID- ORCID: 0000-0003-0021-5354
AD  - Department of Internal Medicine, Keimyung University School of Medicine, Daegu 
      42601, Korea.
FAU - Lim, Hyun
AU  - Lim H
AUID- ORCID: 0000-0001-6581-6420
AD  - Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym 
      University College of Medicine, Anyang 14068, Korea.
FAU - Kim, Do Hoon
AU  - Kim DH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul 05505, Korea.
FAU - Endoscopic Therapy And Instrument Research Group Under The Korean Society Of 
      Neurogastroenterology And Motility
AU  - Endoscopic Therapy And Instrument Research Group Under The Korean Society Of 
      Neurogastroenterology And Motility
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220412
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9031147
OTO - NOTNLM
OT  - fundoplication
OT  - gastroesophageal reflux disease
OT  - plication
OT  - proton pump inhibitor
OT  - radiofrequency
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/24 06:01
PMCR- 2022/04/12
CRDT- 2022/04/23 01:07
PHST- 2022/03/21 00:00 [received]
PHST- 2022/04/06 00:00 [revised]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/04/23 01:07 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/24 06:01 [medline]
PHST- 2022/04/12 00:00 [pmc-release]
AID - jpm12040621 [pii]
AID - jpm-12-00621 [pii]
AID - 10.3390/jpm12040621 [doi]
PST - epublish
SO  - J Pers Med. 2022 Apr 12;12(4):621. doi: 10.3390/jpm12040621.