PMID- 35455945
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220716
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 8
DP  - 2022 Apr 8
TI  - Brain Microvascular Pericytes-More than Bystanders in Breast Cancer Brain 
      Metastasis.
LID - 10.3390/cells11081263 [doi]
LID - 1263
AB  - Brain tissue contains the highest number of perivascular pericytes compared to 
      other organs. Pericytes are known to regulate brain perfusion and to play an 
      important role within the neurovascular unit (NVU). The high phenotypic and 
      functional plasticity of pericytes make this cell type a prime candidate to aid 
      physiological adaptations but also propose pericytes as important modulators in 
      diverse pathologies in the brain. This review highlights known phenotypes of 
      pericytes in the brain, discusses the diverse markers for brain pericytes, and 
      reviews current in vitro and in vivo experimental models to study pericyte 
      function. Our current knowledge of pericyte phenotypes as it relates to 
      metastatic growth patterns in breast cancer brain metastasis is presented as an 
      example for the crosstalk between pericytes, endothelial cells, and metastatic 
      cells. Future challenges lie in establishing methods for real-time monitoring of 
      pericyte crosstalk to understand causal events in the brain metastatic process.
FAU - Ippolitov, Danyyl
AU  - Ippolitov D
AUID- ORCID: 0000-0002-4258-7677
AD  - Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, 
      MB R3E 0J9, Canada.
FAU - Arreza, Leanne
AU  - Arreza L
AD  - Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, 
      MB R3E 0J9, Canada.
FAU - Munir, Maliha Nuzhat
AU  - Munir MN
AD  - Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, 
      MB R3E 0J9, Canada.
FAU - Hombach-Klonisch, Sabine
AU  - Hombach-Klonisch S
AUID- ORCID: 0000-0001-8071-2486
AD  - Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, 
      MB R3E 0J9, Canada.
AD  - Department of Pathology, University of Manitoba, Winnipeg, MB R3E 0Z2, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220408
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Brain
MH  - *Brain Neoplasms/metabolism
MH  - *Breast Neoplasms/pathology
MH  - Endothelial Cells
MH  - Female
MH  - Humans
MH  - Pericytes/metabolism
PMC - PMC9028330
OTO - NOTNLM
OT  - NVU
OT  - brain
OT  - breast-to-brain metastasis
OT  - pericyte markers
OT  - pericyte study models
OT  - pericytes
COIS- The authors declare that they have no competing interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/04/08
CRDT- 2022/04/23 01:08
PHST- 2022/03/07 00:00 [received]
PHST- 2022/04/06 00:00 [revised]
PHST- 2022/04/06 00:00 [accepted]
PHST- 2022/04/23 01:08 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - cells11081263 [pii]
AID - cells-11-01263 [pii]
AID - 10.3390/cells11081263 [doi]
PST - epublish
SO  - Cells. 2022 Apr 8;11(8):1263. doi: 10.3390/cells11081263.