PMID- 35456292 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 8 DP - 2022 Apr 14 TI - Sex Differences in Cardiovascular Prevention in Type 2: Diabetes in a Real-World Practice Database. LID - 10.3390/jcm11082196 [doi] LID - 2196 AB - Women with type 2 diabetes mellitus (T2DM) have a 40% excess risk of cardiovascular diseases (CVD) compared to men due to the interaction between sex and gender factors in the development, risk, and outcomes of the disease. Our aim was to assess differences between women and men with T2DM in the management and degree of control of cardiovascular risk factors (CVRF). This was a matched cross-sectional study including 140,906 T2DM subjects without previous CVD and 39,186 T2DM subjects with prior CVD obtained from the System for the Development of Research in Primary Care (SIDIAP) database. The absolute and relative differences between means or proportions were calculated to assess sex differences. T2DM women without previous CVD showed higher levels of total cholesterol (12.13 mg/dL (0.31 mmol/L); 95% CI = 11.9-12.4) and low-density lipoprotein cholesterol (LDL-c; 5.50 mg/dL (0.14 mmol/L); 95% CI = 5.3-5.7) than men. The recommended LDL-c target was less frequently achieved by women as it was the simultaneous control of different CVRF. In secondary prevention, women showed higher levels of total cholesterol (16.89 mg/dL (0.44 mmol/L); 95% CI = 16.5-17.3), higher levels of LDL-c (8.42 mg/dL (0.22 mmol/L); 95% CI = 8.1-8.8), and higher levels of triglycerides (11.34 mg/dL (0.13 mmol/L); 95% CI = 10.3-12.4) despite similar rates of statin prescription. Recommended targets were less often achieved by women, especially LDL-c < 100 mg/dL (2.59 mmol/L). The composite control was 22% less frequent in women than men. In conclusion, there were substantial sex differences in CVRF management of people with diabetes, with women less likely than men to be on LDL-c target, mainly those in secondary prevention. This could be related to the treatment gap between genders. FAU - Ramirez-Morros, Anna AU - Ramirez-Morros A AD - DAP-Cat Group, Unitat de Suport a la Recerca de la Catalunya Central, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 08272 Sant Fruitos de Bages, Spain. AD - Gerencia Territorial de la Catalunya Central, Institut Catala de la Salut, 08272 Sant Fruitos de Bages, Spain. FAU - Franch-Nadal, Josep AU - Franch-Nadal J AD - DAP-Cat Group, Unitat de Suport a la Recerca de Barcelona, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain. AD - Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 08907 Barcelona, Spain. FAU - Real, Jordi AU - Real J AD - DAP-Cat Group, Unitat de Suport a la Recerca de Barcelona, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain. AD - Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 08907 Barcelona, Spain. FAU - Gratacos, Monica AU - Gratacos M AD - DAP-Cat Group, Unitat de Suport a la Recerca de Barcelona, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain. FAU - Mauricio, Didac AU - Mauricio D AUID- ORCID: 0000-0002-2868-0250 AD - DAP-Cat Group, Unitat de Suport a la Recerca de Barcelona, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain. AD - Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 08907 Barcelona, Spain. AD - Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau and Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, Spain. AD - Department of Medicine, University of Vic and Central University of Catalonia, 08500 Vic, Spain. LA - eng PT - Journal Article DEP - 20220414 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 EIN - J Clin Med. 2022 Aug 02;11(15):. PMID: 35956255 PMC - PMC9032335 OTO - NOTNLM OT - cardiovascular diseases OT - diabetes mellitus OT - gender OT - risk factors OT - type 2 COIS- The authors declare no conflict of interest. EDAT- 2022/04/24 06:00 MHDA- 2022/04/24 06:01 PMCR- 2022/04/14 CRDT- 2022/04/23 01:09 PHST- 2022/03/07 00:00 [received] PHST- 2022/04/07 00:00 [revised] PHST- 2022/04/12 00:00 [accepted] PHST- 2022/04/23 01:09 [entrez] PHST- 2022/04/24 06:00 [pubmed] PHST- 2022/04/24 06:01 [medline] PHST- 2022/04/14 00:00 [pmc-release] AID - jcm11082196 [pii] AID - jcm-11-02196 [pii] AID - 10.3390/jcm11082196 [doi] PST - epublish SO - J Clin Med. 2022 Apr 14;11(8):2196. doi: 10.3390/jcm11082196.