PMID- 35457275
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20221207
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 8
DP  - 2022 Apr 18
TI  - Applications of Metal-Organic Frameworks as Drug Delivery Systems.
LID - 10.3390/ijms23084458 [doi]
LID - 4458
AB  - In the last decade, metal organic frameworks (MOFs) have shown great prospective 
      as new drug delivery systems (DDSs) due to their unique properties: these 
      materials exhibit fascinating architectures, surfaces, composition, and a rich 
      chemistry of these compounds. The DSSs allow the release of the active 
      pharmaceutical ingredient to accomplish a desired therapeutic response. Over the 
      past few decades, there has been exponential growth of many new classes of 
      coordination polymers, and MOFs have gained popularity over other identified 
      systems due to their higher biocompatibility and versatile loading capabilities. 
      This review presents and assesses the most recent research, findings, and 
      challenges associated with the use of MOFs as DDSs. Among the most commonly used 
      MOFs for investigated-purpose MOFs, coordination polymers and metal complexes 
      based on synthetic and natural polymers, are well known. Specific attention is 
      given to the stimuli- and multistimuli-responsive MOFs-based DDSs. Of great 
      interest in the COVID-19 pandemic is the use of MOFs for combination therapy and 
      multimodal systems.
FAU - Maranescu, Bianca
AU  - Maranescu B
AD  - Coriolan Dragulescu Institute of Chemistry, 24 Mihai Viteazul Blv., 300223 
      Timisoara, Romania.
AD  - Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West 
      University Timisoara, 16 Pestalozzi Street, 300115 Timisoara, Romania.
FAU - Visa, Aurelia
AU  - Visa A
AUID- ORCID: 0000-0003-4968-4709
AD  - Coriolan Dragulescu Institute of Chemistry, 24 Mihai Viteazul Blv., 300223 
      Timisoara, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220418
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Polymers)
SB  - IM
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Metal-Organic Frameworks/chemistry
MH  - Pandemics
MH  - Polymers
MH  - Prospective Studies
MH  - *COVID-19 Drug Treatment
PMC - PMC9026733
OTO - NOTNLM
OT  - drug delivery systems
OT  - encapsulation
OT  - metal organic frameworks
OT  - stimulus
OT  - surface modification
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/04/18
CRDT- 2022/04/23 01:11
PHST- 2022/03/21 00:00 [received]
PHST- 2022/04/06 00:00 [revised]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/04/23 01:11 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/04/18 00:00 [pmc-release]
AID - ijms23084458 [pii]
AID - ijms-23-04458 [pii]
AID - 10.3390/ijms23084458 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Apr 18;23(8):4458. doi: 10.3390/ijms23084458.