PMID- 35458153
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 8
DP  - 2022 Apr 12
TI  - Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy-A 
      Narrative Review.
LID - 10.3390/nu14081591 [doi]
LID - 1591
AB  - Despite the fact that knowledge on obstetrical management of Inflammatory Bowel 
      Diseases (IBDs) has greatly improved over the years, many patients still actively 
      avoid pregnancy for fear of adverse maternal or neonatal outcomes, of adverse 
      effects of pregnancy on the disease activity, of eventual IBD inheritance, or of 
      an increased risk of congenital malformations. Indeed, though data prove that 
      fertility is hardly affected by the disease, a reduced birth rate is nevertheless 
      observed in patients with IBD. Misconceptions on the safety of drugs during 
      gestation and breastfeeding may influence patient choice and negatively affect 
      their serenity during pregnancy or lactation. Moreover, physicians often showed 
      concerns about starting IBD medications before and during pregnancy and did not 
      feel adequately trained on the safety of IBD therapies. IBD-expert 
      gastroenterologists and gynecologists should discuss pregnancy and breastfeeding 
      issues with patients when starting or changing medications in order to provide 
      appropriate information; therefore, pre-conception counselling on an 
      individualized basis should be mandatory for all patients of reproductive age to 
      reassure them that maintaining disease remission and balancing the eventual 
      obstetrical risks is possible.
FAU - Ronchetti, Camilla
AU  - Ronchetti C
AUID- ORCID: 0000-0003-2176-8513
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
AD  - Division of Gynecology and Reproductive Medicine, Fertility Center, Department of 
      Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, 
      Italy.
FAU - Cirillo, Federico
AU  - Cirillo F
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
AD  - Division of Gynecology and Reproductive Medicine, Fertility Center, Department of 
      Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, 
      Italy.
FAU - Di Segni, Noemi
AU  - Di Segni N
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
AD  - Division of Gynecology and Reproductive Medicine, Fertility Center, Department of 
      Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, 
      Italy.
FAU - Cristodoro, Martina
AU  - Cristodoro M
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
FAU - Busnelli, Andrea
AU  - Busnelli A
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
AD  - Division of Gynecology and Reproductive Medicine, Fertility Center, Department of 
      Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, 
      Italy.
FAU - Levi-Setti, Paolo Emanuele
AU  - Levi-Setti PE
AUID- ORCID: 0000-0003-1024-4386
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20090 Milan, Italy.
AD  - Division of Gynecology and Reproductive Medicine, Fertility Center, Department of 
      Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220412
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Breast Feeding
MH  - Chronic Disease
MH  - Female
MH  - Fertility
MH  - Humans
MH  - Infant, Newborn
MH  - *Inflammatory Bowel Diseases/drug therapy
MH  - Pregnancy
MH  - *Pregnancy Complications/therapy
MH  - Reproductive Health
PMC - PMC9026369
OTO - NOTNLM
OT  - Crohn's disease
OT  - breastfeeding
OT  - diet
OT  - gut microbiota
OT  - infertility
OT  - inflammation
OT  - inflammatory bowel diseases
OT  - malabsorption
OT  - pregnancy
OT  - ulcerative colitis
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/04/12
CRDT- 2022/04/23 01:14
PHST- 2022/03/18 00:00 [received]
PHST- 2022/04/05 00:00 [revised]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/04/23 01:14 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/04/12 00:00 [pmc-release]
AID - nu14081591 [pii]
AID - nutrients-14-01591 [pii]
AID - 10.3390/nu14081591 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 12;14(8):1591. doi: 10.3390/nu14081591.