PMID- 35458220
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 8
DP  - 2022 Apr 15
TI  - The Extracellular Mass to Body Cell Mass Ratio as a Predictor of Mortality Risk 
      in Hemodialysis Patients.
LID - 10.3390/nu14081659 [doi]
LID - 1659
AB  - The extracellular mass/body cell mass ratio (ECM/BCM ratio) is a novel indicator 
      of nutritional and hydration status in hemodialysis (HD) patients. This study 
      aimed to explore the ECM/BCM ratio as a predictor of mortality risk with 
      nutritional-inflammatory markers in HD patients. A prospective observational 
      study was conducted in 90 HD patients (male: 52.2%; DM: 25.60%). Clinical and 
      biochemical parameters [serum albumin, serum C-reactive protein (s-CRP), 
      interleukine-6 (IL-6)] were analysed and bioelectrical impedance analysis (BIA) 
      was performed. Protein-energy wasting syndrome (PEW) was diagnosed using 
      malnutrition-inflammation score (MIS). Based on BIA-derived measurements, the 
      ECM/BCM ratio with a cut-off point of 1.20 was used as a PEW-fluid overload 
      indicator. Comorbidity by Charlson index and hospital admissions were measured. 
      Out of 90 HD patients followed up for 36 months, 20 patients (22.22%) died. PEW 
      was observed in 24 survivors (34.28%) and all non-survivors. The ECM/BCM ratio 
      was directly correlated with MIS, s-CRP, Charlson index and hospital admissions 
      but was negatively correlated with phase angle and s-albumin (all, p < 0.001). 
      Values of the ECM/BCM ratio >/= 1.20 were associated with higher probability of 
      all-cause mortality (p = 0.002). The ECM/BCM ratio >/= 1.20, IL-6 >/= 3.1 pg/mL, 
      s-CRP and s-albumin >/= 3.8 g/dL and Charlson index were significantly associated 
      with all-cause mortality risk in multivariate adjusted analysis. This study 
      demonstrates that the ECM/BCM ratio >/= 1.20 as a nutritional marker and/or fluid 
      overload indicator had a significant prognostic value of death risk in HD 
      patients.
FAU - Ruperto, Mar
AU  - Ruperto M
AUID- ORCID: 0000-0002-8790-4007
AD  - Department of Pharmaceutical & Health Sciences, Faculty of Pharmacy, Universidad 
      San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Alcorcon, 28925 
      Madrid, Spain.
AD  - Grupo USP-CEU de Excelencia "Nutricion para la vida (Nutrition for Life)", Ref: 
      E02/0720, Alcorcon, 28925 Madrid, Spain.
FAU - Barril, Guillermina
AU  - Barril G
AUID- ORCID: 0000-0003-4067-634X
AD  - Nephrology Department, Hospital Universitario La Princesa, 28006 Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20220415
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Albumin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers
MH  - Body Composition
MH  - C-Reactive Protein/metabolism
MH  - Cachexia/etiology
MH  - Electric Impedance
MH  - Female
MH  - Humans
MH  - Inflammation/etiology
MH  - Interleukin-6/metabolism
MH  - *Kidney Failure, Chronic/complications
MH  - Male
MH  - *Malnutrition/complications/etiology
MH  - Nutritional Status
MH  - Renal Dialysis/adverse effects
MH  - Serum Albumin/metabolism
MH  - *Water-Electrolyte Imbalance/complications/etiology
PMC - PMC9029814
OTO - NOTNLM
OT  - bioelectric impedance analysis
OT  - extracellular mass to body cell mass ratio
OT  - fluid overload
OT  - haemodialysis
OT  - interleukine-6
OT  - protein-energy wasting
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/24 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/04/15
CRDT- 2022/04/23 01:14
PHST- 2022/03/14 00:00 [received]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/04/23 01:14 [entrez]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/04/15 00:00 [pmc-release]
AID - nu14081659 [pii]
AID - nutrients-14-01659 [pii]
AID - 10.3390/nu14081659 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 15;14(8):1659. doi: 10.3390/nu14081659.