PMID- 35459618
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220804
IS  - 1879-0305 (Electronic)
IS  - 1359-6101 (Linking)
VI  - 66
DP  - 2022 Aug
TI  - The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus 
      associated inflammatory microenvironment.
PG  - 15-25
LID - S1359-6101(22)00024-7 [pii]
LID - 10.1016/j.cytogfr.2022.04.002 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a classic metaflammatory disease, and the 
      inflammatory states of the pancreatic islet and insulin target organs have been 
      well confirmed. However, abundant evidence demonstrates that there are countless 
      connections between these organs in the presence of a low degree of inflammation. 
      In this review, we focus on cell-cell crosstalk among local cells in the islet 
      and organ-organ crosstalk among insulin-related organs. In contrast to that in 
      acute inflammation, macrophages are the dominant immune cells causing 
      inflammation in the islets and insulin target organs in T2DM. In the inflammatory 
      microenvironment (IME) of the islet, cell-cell crosstalk involving local 
      macrophage polarization and proinflammatory cytokine production impair insulin 
      secretion by beta-cells. Furthermore, organ-organ crosstalk, including the 
      gut-brain-pancreas axis and interactions among insulin-related organs during 
      inflammation, reduces insulin sensitivity and induces endocrine dysfunction. 
      Therefore, this crosstalk ultimately results in a cascade leading to beta-cell 
      dysfunction. These findings could have broad implications for therapies aimed at 
      treating T2DM.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Gao, Danni
AU  - Gao D
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China; Peking University Fifth School of Clinical Medicine, Beijing 
      100730, PR China.
FAU - Jiao, Juan
AU  - Jiao J
AD  - Department of Clinical Laboratory, the Seventh Medical Centre of Chinese PLA 
      General Hospital, Beijing 100700, PR China.
FAU - Wang, Zhaoping
AU  - Wang Z
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Huang, Xiuqing
AU  - Huang X
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Ni, Xiaolin
AU  - Ni X
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Fang, Sihang
AU  - Fang S
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Zhou, Qi
AU  - Zhou Q
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Zhu, Xiaoquan
AU  - Zhu X
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Sun, Liang
AU  - Sun L
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Yang, Ze
AU  - Yang Z
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China.
FAU - Yuan, Huiping
AU  - Yuan H
AD  - The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of 
      Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 
      Hospital/National Center of Gerontology of National Health Commission, Beijing 
      100730, PR China; Peking University Fifth School of Clinical Medicine, Beijing 
      100730, PR China. Electronic address: yuanhuiping@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220416
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Insulin)
SB  - IM
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Inflammation
MH  - Insulin
MH  - *Insulin-Secreting Cells
MH  - *Islets of Langerhans
OTO - NOTNLM
OT  - Inflammatory microenvironment
OT  - Islet
OT  - Metaflammation
OT  - Type 2 diabetes mellitus
OT  - beta-cell dysfunction
EDAT- 2022/04/24 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/04/23 05:20
PHST- 2022/02/22 00:00 [received]
PHST- 2022/04/08 00:00 [revised]
PHST- 2022/04/11 00:00 [accepted]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/04/23 05:20 [entrez]
AID - S1359-6101(22)00024-7 [pii]
AID - 10.1016/j.cytogfr.2022.04.002 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2022 Aug;66:15-25. doi: 
      10.1016/j.cytogfr.2022.04.002. Epub 2022 Apr 16.