PMID- 35460420
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20230916
IS  - 1464-3804 (Electronic)
IS  - 0267-8357 (Print)
IS  - 0267-8357 (Linking)
VI  - 37
IP  - 2
DP  - 2022 May 4
TI  - The role of human umbilical cord mesenchymal stem cells-derived exosomal 
      microRNA-431-5p in survival and prognosis of colorectal cancer patients.
PG  - 164-171
LID - 10.1093/mutage/geac007 [doi]
AB  - We aim to discuss the role of miR-431-5p in colorectal cancer (CRC) progression 
      via regulating peroxiredoxin 1 (PRDX1). miR-431-5p and PRDX1 expression were 
      detected in CRC tissues and cells, and the relationship between miR-431-5p 
      expression and prognosis of CRC patients was analyzed. Exosomes were extracted 
      from human umbilical cord mesenchymal stem cells (hUCMSCs) and co-cultured with 
      LoVo cells. MTT assay, flow cytometry and Transwell assay were implemented to 
      test cell viability, apoptosis and invasion and migration ability, respectively. 
      The tumor growth was determined as well, and the binding relation between 
      miR-431-5p and PRDX1 was confirmed. miR-431-5p was downregulated and PRDX1 was 
      upregulated in CRC, and miR-431-5p downregulation was associated with poor 
      prognosis. hUCMSC-Exos suppressed the malignant behaviors of LoVo cells, and 
      overexpression of miR-431-5p further aggravated the inhibitory effect of 
      hUCMSC-Exos on LoVo cells. hUCMSC-Exos inhibited PRDX1 expression via miR-431-5p. 
      PRDX1 was targeted by miR-431-5p. miR-431-5p serves as a prognostic biomarker in 
      CRC, and hUCMSC-Exos transfer of miR-431-5p decelerates CRC cell growth by 
      inhibiting PRDX1.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the UK 
      Environmental Mutagen Society.
FAU - Qu, Muwen
AU  - Qu M
AD  - Anorectal Department of Guang'anmen Hospital of Chinese Academy of Chinese 
      Medical Sciences, No. 5, Beixiange, Xicheng District, 100053 Beijing, China.
FAU - Li, Junyi
AU  - Li J
AD  - Surgical Department of Guang'anmen Hospital of Chinese Academy of Chinese Medical 
      Sciences, No. 5, Beixiange, Xicheng District, 100053 Beijing, China.
FAU - Hong, Zifu
AU  - Hong Z
AD  - Anorectal Department of Guang'anmen Hospital of Chinese Academy of Chinese 
      Medical Sciences, No. 5, Beixiange, Xicheng District, 100053 Beijing, China.
FAU - Jia, Fei
AU  - Jia F
AD  - Anorectal Department of Guang'anmen Hospital of Chinese Academy of Chinese 
      Medical Sciences, No. 5, Beixiange, Xicheng District, 100053 Beijing, China.
FAU - He, Yinghua
AU  - He Y
AD  - Anorectal Department of Guang'anmen Hospital of Chinese Academy of Chinese 
      Medical Sciences, No. 5, Beixiange, Xicheng District, 100053 Beijing, China.
FAU - Yuan, Lingling
AU  - Yuan L
AD  - Department of Dermatology, Dongzhimen Hospital, Beijing University of Traditional 
      Chinese Medicine, No. 5, Haiyuncang, Dongcheng District, 100700 Beijing, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (MicroRNAs)
RN  - 0 (MIRN431 microRNA, human)
SB  - IM
MH  - Humans
MH  - *MicroRNAs/genetics/metabolism
MH  - *Exosomes/genetics/metabolism
MH  - *Mesenchymal Stem Cells/pathology
MH  - Umbilical Cord/metabolism/pathology
MH  - *Colorectal Neoplasms/metabolism
MH  - Cell Proliferation/genetics
PMC - PMC9071100
OTO - NOTNLM
OT  - colorectal cancer
OT  - human umbilical cord mesenchymal stem cells-derived exosome
OT  - microRNA-431-5p
OT  - peroxiredoxin 1
OT  - prognosis
OT  - survival
EDAT- 2022/04/24 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/04/23
CRDT- 2022/04/23 12:04
PHST- 2021/11/03 00:00 [received]
PHST- 2022/02/16 00:00 [accepted]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/04/23 12:04 [entrez]
PHST- 2022/04/23 00:00 [pmc-release]
AID - 6573282 [pii]
AID - geac007 [pii]
AID - 10.1093/mutage/geac007 [doi]
PST - ppublish
SO  - Mutagenesis. 2022 May 4;37(2):164-171. doi: 10.1093/mutage/geac007.