PMID- 35460440
OWN - NLM
STAT- MEDLINE
DCOM- 20230126
LR  - 20230325
IS  - 1432-0460 (Electronic)
IS  - 0179-051X (Print)
IS  - 0179-051X (Linking)
VI  - 38
IP  - 1
DP  - 2023 Feb
TI  - Spontaneous Swallowing Frequency in Post-Stroke Patients with and Without 
      Oropharyngeal Dysphagia: An Observational Study.
PG  - 200-210
LID - 10.1007/s00455-022-10451-3 [doi]
AB  - Oropharyngeal dysphagia (OD) is a frequent complication after stroke (PSOD) that 
      increases morbidity and mortality. Early detection of PSOD is essential to reduce 
      morbidity and mortality in patients with acute stroke. In recent years, an 
      association between reduced spontaneous swallowing frequency (SSF) and OD has 
      been described. Likewise, the reduction of saliva substance P (SP) concentration 
      has been associated with an increased risk of aspiration and a decrease in SSF. 
      In this study we aimed to compare SSF, salivary SP concentration, hydration and 
      nutritional status in post-stroke (PS) patients with and without OD. We included 
      45 acute PS patients (4.98 +/- 2.80 days from stroke onset, 62.22% men, 
      71.78 +/- 13.46 year). The Volume-Viscosity Swallowing Test (V-VST) was performed 
      for clinical diagnosis of OD. SSF/minute was assessed through 10-min 
      neurophysiological surface recordings including suprahyoid-electromyography and 
      cricothyroid-accelerometry. Saliva samples were collected with a Salivette(R) to 
      determine SP by ELISA. Hydration status was assessed by bioimpedance. Nutritional 
      status was evaluated by Mini Nutritional Assessment Short Form (MNA-sf) and blood 
      analysis. Twenty-seven PS patients (60%) had OD; 19 (40%), impaired safety of 
      swallow. SSF was significantly reduced in PSOD, 0.23 +/- 0.18 and PSOD with 
      impaired safety, 0.22 +/- 0.18 vs 0.48 +/- 0.29 swallows/minute in PS without OD 
      (PSnOD); (both p < 0.005). Nutritional risk was observed in 62.92% PSOD vs 11.11% 
      PSnOD (p = 0.007) and visceral protein markers were also significantly reduced in 
      PSOD (p < 0.05). Bioimpedance showed intracellular dehydration in 37.50% PSOD vs 
      none in PSnOD. There were no differences for saliva SP concentrations. SSF is 
      significantly reduced in PSOD in comparison with PSnOD. Acute PSOD patients 
      present poor nutritional status, hydropenia, and high risk for respiratory 
      complications.
CI  - (c) 2022. The Author(s).
FAU - Alvarez-Larruy, Marta
AU  - Alvarez-Larruy M
AD  - Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de 
      Mataro, Universitat Autonoma de Barcelona, Mataro, Spain.
AD  - Department of Neurology, Hospital de Mataro, Mataro, Spain.
FAU - Tomsen, Noemi
AU  - Tomsen N
AD  - Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de 
      Mataro, Universitat Autonoma de Barcelona, Mataro, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas Y Digestivas 
      (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain.
FAU - Guanyabens, Nicolau
AU  - Guanyabens N
AD  - Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de 
      Mataro, Universitat Autonoma de Barcelona, Mataro, Spain.
AD  - Department of Neurology, Hospital de Mataro, Mataro, Spain.
FAU - Palomeras, Ernest
AU  - Palomeras E
AD  - Department of Neurology, Hospital de Mataro, Mataro, Spain.
FAU - Clave, Pere
AU  - Clave P
AUID- ORCID: 0000-0002-0696-8560
AD  - Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de 
      Mataro, Universitat Autonoma de Barcelona, Mataro, Spain. 
      pere.clave@ciberehd.org.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas Y Digestivas 
      (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain. 
      pere.clave@ciberehd.org.
AD  - Department of Surgery, Hospital de Mataro, Universitat Autonoma de Barcelona, 
      Carretera de Cirera s/n 08304, Mataro, Spain. pere.clave@ciberehd.org.
FAU - Nascimento, Weslania
AU  - Nascimento W
AD  - Gastrointestinal Physiology Laboratory, Department of Surgery, Hospital de 
      Mataro, Universitat Autonoma de Barcelona, Mataro, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220423
PL  - United States
TA  - Dysphagia
JT  - Dysphagia
JID - 8610856
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Deglutition/physiology
MH  - *Deglutition Disorders/etiology/complications
MH  - *Stroke/complications
MH  - Nutritional Status
MH  - *Malnutrition
PMC - PMC9034075
OTO - NOTNLM
OT  - Deglutition
OT  - Oropharyngeal Dysphagia
OT  - Spontaneous swallowing frequency
OT  - Stroke
OT  - Swallow
COIS- The authors have no conflicts of interest to declare that are relevant to the 
      content of this article.
EDAT- 2022/04/24 06:00
MHDA- 2023/01/27 06:00
PMCR- 2022/04/23
CRDT- 2022/04/23 12:04
PHST- 2021/11/10 00:00 [received]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/04/24 06:00 [pubmed]
PHST- 2023/01/27 06:00 [medline]
PHST- 2022/04/23 12:04 [entrez]
PHST- 2022/04/23 00:00 [pmc-release]
AID - 10.1007/s00455-022-10451-3 [pii]
AID - 10451 [pii]
AID - 10.1007/s00455-022-10451-3 [doi]
PST - ppublish
SO  - Dysphagia. 2023 Feb;38(1):200-210. doi: 10.1007/s00455-022-10451-3. Epub 2022 Apr 
      23.