PMID- 35462287
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220511
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 215
DP  - 2022 Jun 5
TI  - Homochiral iron-based gamma-cyclodextrin metal-organic framework for stereoisomer 
      separation in the open tubular capillary electrochromatography.
PG  - 114777
LID - S0731-7085(22)00198-4 [pii]
LID - 10.1016/j.jpba.2022.114777 [doi]
AB  - Metal organic frameworks (MOFs), as a novel separation mediums, have in recent 
      years attracted wide consideration in capillary electrochromatography (CEC). 
      However, the instability of frameworks limited the application of the MOF-based 
      chiral separation capillary. Herein, Iron-based gamma-cyclodextrin metal-organic 
      framework (Fe-CD-MOF) with mesoporous was developed as the chiral stationary 
      phase in open tubular capillary electrochromatography column (OT-CEC) for the 
      stereoisomer separation of fourteen chiral drugs and one chiral alcohol. The 
      capillary column with MOF coating exhibited the best performance (resolution 
      value: 17.07) for anisodamine in any MOF-based capillary column that has never 
      been reported. Moreover, the effect of pH, buffer concentration, and methanol 
      content has been investigated. The novel coated capillary was also applied for 
      the quantitative analysis of a real sample. The Fe-CD-MOF coated capillary showed 
      outstanding repeatability and stability, with the satisfactory relative standard 
      deviations (RSDs) for intra-day, inter-day, and column-to-column. Finally, the 
      enantioseparation mechanism of the Fe-CD-MOF coated capillary was evaluated by 
      adsorption kinetic experiments. In summary, this work indicated the novel and 
      renewable Fe-CD-MOF was a potential chiral stationary phase in CEC chiral 
      separation.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Wang, Chen
AU  - Wang C
AD  - Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of 
      Education), China Pharmaceutical University, Nanjing 210009, PR China; State Key 
      Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, 
      PR China.
FAU - Zhu, Dongyang
AU  - Zhu D
AD  - Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of 
      Education), China Pharmaceutical University, Nanjing 210009, PR China; State Key 
      Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, 
      PR China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of 
      Education), China Pharmaceutical University, Nanjing 210009, PR China; State Key 
      Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, 
      PR China.
FAU - Du, Yingxiang
AU  - Du Y
AD  - Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of 
      Education), China Pharmaceutical University, Nanjing 210009, PR China; State Key 
      Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, 
      PR China. Electronic address: du_yingxiang@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220419
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (gamma-Cyclodextrins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - *Capillary Electrochromatography/methods
MH  - Iron
MH  - *Metal-Organic Frameworks/chemistry
MH  - Stereoisomerism
MH  - *gamma-Cyclodextrins
OTO - NOTNLM
OT  - Electrochromatography
OT  - Fe-CD-MOF
OT  - Homochiral metal organic framework
OT  - Open tubular capillary
OT  - Stereoisomer separation
EDAT- 2022/04/25 06:00
MHDA- 2022/05/12 06:00
CRDT- 2022/04/24 20:27
PHST- 2022/02/23 00:00 [received]
PHST- 2022/04/06 00:00 [revised]
PHST- 2022/04/16 00:00 [accepted]
PHST- 2022/04/25 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2022/04/24 20:27 [entrez]
AID - S0731-7085(22)00198-4 [pii]
AID - 10.1016/j.jpba.2022.114777 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2022 Jun 5;215:114777. doi: 10.1016/j.jpba.2022.114777. Epub 
      2022 Apr 19.