PMID- 35462734
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Tractography in Type 2 Diabetes Mellitus With Subjective Memory Complaints: A 
      Diffusion Tensor Imaging Study.
PG  - 800420
LID - 10.3389/fnins.2021.800420 [doi]
LID - 800420
AB  - The brain white matter (WM) structural injury caused by type 2 diabetes mellitus 
      (T2DM) has been linked to cognitive impairment. However, the focus was mainly on 
      the mild cognitive impairment (MCI) stage in most previous studies, with little 
      attention made to subjective memory complaints (SMC). The main purpose of the 
      current study was to investigate the characteristics of WM injury in T2DM 
      patients and its correlation with SMC symptoms. In a group of 66 participants (33 
      HC and 33 T2DM-S), pointwise differences along WM tracts were identified using 
      the automated fiber quantification (AFQ) approach. Then we investigated the 
      utility of DTI properties along major WM tracts as features to distinguish 
      patients with T2DM-S from HC via the support vector machine (SVM). Based on AFQ 
      analysis, 10 primary fiber tracts that represent the subtle alterations of WM in 
      T2DM-S were identified. Lower fractional anisotropy (FA) in the right SLF tract 
      (r = -0.538, p = 0.0013), higher radial diffusivity (RD) in the thalamic 
      radiation (TR) tract (r = 0.433, p = 0.012), and higher mean diffusivity (MD) in 
      the right inferior fronto-occipital fasciculus (IFOF) tract (r = 0.385, p = 
      0.0029) were significantly associated with a long period of disease. Decreased 
      axial diffusivity (AD) in the left arcuate was associated with HbA(1c) (r = 
      -0.368, p = 0.049). In addition, we found a significant negative correlation 
      between delayed recall and abnormal MD in the left corticospinal tract (r = 
      -0.546, p = 0.001). The FA of the right SLF tracts and bilateral arcuate can be 
      used to differentiate the T2DM-S and the HC at a high accuracy up to 88.45 and 
      87.8%, respectively. In conclusion, WM microstructure injury in T2DM may be 
      associated with SMC, and these abnormalities identified by DTI can be used as an 
      effective biomarker.
CI  - Copyright (c) 2022 Wang, Ma, Liu, Bai, Ai, Zhang, Hu and Zhang.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Ma, Laiyang
AU  - Ma L
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Liu, Guangyao
AU  - Liu G
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Bai, Wenjuan
AU  - Bai W
AD  - Department of Endocrine, Lanzhou University Second Hospital, Lanzhou, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical Science, Philips Healthcare, Xi'an, China.
FAU - Zhang, Pengfei
AU  - Zhang P
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Hu, Wanjun
AU  - Hu W
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220406
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9019711
OTO - NOTNLM
OT  - cognitive function
OT  - diffusion tensor imaging
OT  - memory
OT  - type 2 diabetes
OT  - white matter
COIS- KA was employed by the company Philips Healthcare. The remaining authors declare 
      that the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2022/04/26 06:00
MHDA- 2022/04/26 06:01
PMCR- 2021/01/01
CRDT- 2022/04/25 05:10
PHST- 2021/10/23 00:00 [received]
PHST- 2021/12/31 00:00 [accepted]
PHST- 2022/04/25 05:10 [entrez]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/04/26 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.800420 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Apr 6;15:800420. doi: 10.3389/fnins.2021.800420. eCollection 
      2021.