PMID- 35463864
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2190-1678 (Print)
IS  - 2190-1686 (Electronic)
IS  - 2190-1678 (Linking)
VI  - 13
IP  - 2
DP  - 2022 Apr
TI  - Anthropometric measurements and serum TNF-alpha, IL-6 and adiponectin in type 2 
      diabetes.
PG  - 396-406
LID - 10.1007/s13340-021-00553-y [doi]
AB  - OBJECTIVE: To investigate the effect of anthropometric measurements on serum 
      adiponectin and inflammatory markers in Type 2 diabetes mellitus (T2DM). METHODS: 
      This study was conducted with 46 subjects newly diagnosed with T2DM and 30 
      healthy volunteers free from pre-existing inflammatory disease, cancer, Type 1 
      diabetes and using any medications. Demographic, clinical and anthropometric data 
      were collected. The anthropometric measurements and insulin resistance components 
      (fasting plasma glucose (FPG), HbA1c, fasting insulin, HOMA-IR) were analyzed. 
      HOMA-beta values were calculated to measure pancreatic beta cell functions. Serum 
      C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 
      (IL-6) levels were measured to determine the presence of inflammation and serum 
      adiponectin levels were assessed. RESULTS: Individuals with T2DM showed higher 
      body mass index (BMI), body fat percentage, waist circumference (WC), 
      waist-to-hip ratio and waist-to-height ratio values. Serum cytokine levels were 
      higher but adiponectin levels were lower in diabetic patients. Serum 
      concentrations of CRP were found to be significantly correlated with WC and body 
      fat mass (kg and %); TNF-alpha was significantly associated with WC and waist-to-hip 
      ratio in individuals with T2DM. Adiponectin was negatively correlated with WC and 
      waist-to-hip ratio in healthy subjects. CONCLUSIONS: Prevention of obesity and 
      central adiposity is an important factor to prevent elevations in inflammatory 
      cytokine levels in diabetic patients.
CI  - (c) The Japan Diabetes Society 2021.
FAU - Yalcin, Tuba
AU  - Yalcin T
AUID- ORCID: 0000-0002-4820-8180
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Izmir Katip 
      Celebi University, 35620 Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 0004 0454 
      9420
FAU - Oguz, Seda Hanife
AU  - Oguz SH
AUID- ORCID: 0000-0002-7781-944X
AD  - Department of Endocrinology, Division of Endocrinology and Metabolism, Hacettepe 
      University, 06100 Ankara, Turkey. GRID: grid.14442.37. ISNI: 0000 0001 2342 7339
FAU - Bayraktar, Miyase
AU  - Bayraktar M
AUID- ORCID: 0000-0002-6064-5615
AD  - Department of Endocrinology, Division of Endocrinology and Metabolism, Hacettepe 
      University, 06100 Ankara, Turkey. GRID: grid.14442.37. ISNI: 0000 0001 2342 7339
FAU - Rakicioglu, Neslisah
AU  - Rakicioglu N
AUID- ORCID: 0000-0001-8763-7407
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe 
      University, 06100 Ankara, Turkey. GRID: grid.14442.37. ISNI: 0000 0001 2342 7339
LA  - eng
PT  - Journal Article
DEP - 20211029
PL  - Japan
TA  - Diabetol Int
JT  - Diabetology international
JID - 101553224
PMC - PMC8980124
OTO - NOTNLM
OT  - Adiponectin
OT  - Inflammatory cytokines
OT  - Obesity
OT  - Type 2 diabetes mellitus
OT  - Waist circumference
COIS- Conflict of interestNo potential conflicts of interest relevant to this article 
      were reported.
EDAT- 2022/04/26 06:00
MHDA- 2022/04/26 06:01
PMCR- 2022/10/29
CRDT- 2022/04/25 05:25
PHST- 2021/07/21 00:00 [received]
PHST- 2021/10/14 00:00 [accepted]
PHST- 2022/04/25 05:25 [entrez]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/04/26 06:01 [medline]
PHST- 2022/10/29 00:00 [pmc-release]
AID - 553 [pii]
AID - 10.1007/s13340-021-00553-y [doi]
PST - epublish
SO  - Diabetol Int. 2021 Oct 29;13(2):396-406. doi: 10.1007/s13340-021-00553-y. 
      eCollection 2022 Apr.