PMID- 35464048 OWN - NLM STAT- MEDLINE DCOM- 20220510 LR - 20220716 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 11 DP - 2022 TI - Comorbidities and laboratory parameters associated with SARS-CoV-2 infection severity in patients from the southeast of Mexico: a cross-sectional study. PG - 10 LID - 10.12688/f1000research.74023.2 [doi] LID - 10 AB - Background. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic. Among the risk factors associated with the severity of this disease is the presence of several metabolic disorders. For this reason, the aim of this research was to identify the comorbidities and laboratory parameters among COVID-19 patients admitted to the intensive care unit (ICU), comparing the patients who required invasive mechanical ventilation (IMV) with those who did not require IMV, in order to determine the clinical characteristics associated with the COVID-19 severity. Methods. We carried out a cross-sectional study among 152 patients who were admitted to the ICU from April 1 (st) to July 31 (st), 2021, in whom the comorbidities and laboratory parameters associated with the SARS-CoV-2 infection severity were identified. The data of these patients was grouped into two main groups: "patients who required IMV" and "patients who did not require IMV". The nonparametric Mann-Whitney U test for continuous data and the chi2 test for categorical data were used to compare the variables between both groups. Results. Of the 152 COVID-19 patients who were admitted to the ICU, 66 required IMV and 86 did not require IMV. Regarding the comorbidities found in these patients, a higher prevalence of type 2 diabetes mellitus (T2DM), hypertension and obesity was observed among patients who required IMV vs. those who did not require IMV ( p<0.05). Concerning laboratory parameters, only glucose, Interleukin 6 (IL-6), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were significantly higher among patients who required IMV than in those who did not require IMV ( p<0.05). Conclusion. This study performed in a Mexican population indicates that comorbidities such as: T2DM, hypertension and obesity, as well as elevated levels of glucose, IL-6, LDH and CRP are associated with the COVID-19 severity. CI - Copyright: (c) 2022 De la Cruz-Cano E et al. FAU - De la Cruz-Cano, Eduardo AU - De la Cruz-Cano E AD - Division Academica de Ciencias Basicas. CICTAT. Laboratorio de Bioquimica y Biologia Molecular., Universidad Juarez Autonoma de Tabasco, Cunduacan,, Tabasco., 86690, Mexico. AD - Laboratorio de Analisis Clinicos., Secretaria de Salud, Hospital General de Comalcalco., Comalcalco., Tabasco, 86300, Mexico. FAU - Jimenez-Gonzalez, Cristina Del C AU - Jimenez-Gonzalez CDC AD - Division Academica Multidisciplinaria de Comalcalco. Laboratorio de Analisis Clinicos., Universidad Juarez Autonoma de Tabasco., Comalcalco., Tabasco., 86650, Mexico. FAU - Diaz-Gandarilla, Jose A AU - Diaz-Gandarilla JA AD - Division Academica Multidisciplinaria de Comalcalco. Laboratorio de Analisis Clinicos., Universidad Juarez Autonoma de Tabasco., Comalcalco., Tabasco., 86650, Mexico. FAU - Lopez-Victorio, Carlos J AU - Lopez-Victorio CJ AD - Division Academica de Ciencias Basicas. CICTAT. Laboratorio de Bioquimica y Biologia Molecular., Universidad Juarez Autonoma de Tabasco, Cunduacan,, Tabasco., 86690, Mexico. FAU - Escobar-Ramirez, Adelma AU - Escobar-Ramirez A AD - Division Academica de Ciencias Basicas. CICTAT. Laboratorio de Bioquimica y Biologia Molecular., Universidad Juarez Autonoma de Tabasco, Cunduacan,, Tabasco., 86690, Mexico. FAU - Uribe-Lopez, Sheila A AU - Uribe-Lopez SA AD - Division Academica Multidisciplinaria de Jalpa de Mendez. Laboratorio de Inmunologia y Microbiologia Molecular., Universidad Juarez Autonoma de Tabasco, Jalpa de Mendez, Tabasco, 86205, Mexico. FAU - Huerta-Garcia, Elizabeth AU - Huerta-Garcia E AD - Division Academica Multidisciplinaria de Jalpa de Mendez. Laboratorio de Inmunologia y Microbiologia Molecular., Universidad Juarez Autonoma de Tabasco, Jalpa de Mendez, Tabasco, 86205, Mexico. FAU - Ayala-Sumuano, Jorge-Tonatiuh AU - Ayala-Sumuano JT AD - IDIX Biotechnology., IDIX Biotechnology, SA. de C.V, Queretaro, Queretaro, 76235, Mexico. FAU - Morales-Garcia, Vicente AU - Morales-Garcia V AD - Division Academica Multidisciplinaria de Comalcalco. Laboratorio de Analisis Clinicos., Universidad Juarez Autonoma de Tabasco., Comalcalco., Tabasco., 86650, Mexico. FAU - Gutierrez-Lopez, Liliana AU - Gutierrez-Lopez L AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina., Instituto Politecnico Nacional., Ciudad de Mexico, Ciudad de Mexico, 11340, Mexico. FAU - Gonzalez-Garrido, Jose A AU - Gonzalez-Garrido JA AUID- ORCID: 0000-0003-1135-4050 AD - Division Academica de Ciencias Basicas. CICTAT. Laboratorio de Bioquimica y Biologia Molecular., Universidad Juarez Autonoma de Tabasco, Cunduacan,, Tabasco., 86690, Mexico. LA - eng PT - Journal Article DEP - 20220106 PL - England TA - F1000Res JT - F1000Research JID - 101594320 RN - 0 (Interleukin-6) RN - IY9XDZ35W2 (Glucose) SB - IM MH - *COVID-19/epidemiology MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/epidemiology MH - Glucose MH - Humans MH - *Hypertension/epidemiology MH - Interleukin-6 MH - Mexico/epidemiology MH - Obesity MH - SARS-CoV-2 PMC - PMC9005987 OTO - NOTNLM OT - SARS-CoV-2; type 2 diabetes mellitus; hypertension; obesity; laboratory parameters. COIS- No competing interests were disclosed. EDAT- 2022/05/10 06:00 MHDA- 2022/05/11 06:00 PMCR- 2022/04/27 CRDT- 2022/05/09 04:07 PHST- 2022/04/25 00:00 [accepted] PHST- 2022/05/09 04:07 [entrez] PHST- 2022/05/10 06:00 [pubmed] PHST- 2022/05/11 06:00 [medline] PHST- 2022/04/27 00:00 [pmc-release] AID - 10.12688/f1000research.74023.2 [doi] PST - epublish SO - F1000Res. 2022 Jan 6;11:10. doi: 10.12688/f1000research.74023.2. eCollection 2022.