PMID- 35464064
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220728
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise 
      Outlook.
PG  - 865436
LID - 10.3389/fendo.2022.865436 [doi]
LID - 865436
AB  - Chemotherapy is a critical treatment for endocrine-related cancers; however, 
      chemoresistance and disease recurrence remain a challenge. The interplay between 
      cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) 
      promotes drug resistance, known as cell adhesion-mediated drug resistance 
      (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or 
      cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger 
      intracellular signaling that regulates cancer cell stemness maintenance, 
      survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug 
      resistance. To understand these mechanisms, this review focuses on the role of 
      CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.
CI  - Copyright (c) 2022 Ruan, Chen, Xie, Luo, Xu, Ye, Chen, Feng and Wu.
FAU - Ruan, Yongsheng
AU  - Ruan Y
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Chen, Libai
AU  - Chen L
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Xie, Danfeng
AU  - Xie D
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Luo, Tingting
AU  - Luo T
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Xu, Yiqi
AU  - Xu Y
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Ye, Tao
AU  - Ye T
AD  - Department of Endocrinology, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University, Shenzhen, China.
FAU - Chen, Xiaona
AU  - Chen X
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Feng, Xiaoqin
AU  - Feng X
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Wu, Xuedong
AU  - Wu X
AD  - Department of Pediatrics, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220407
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Cadherins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Integrins)
SB  - IM
MH  - Cadherins/metabolism/pharmacology
MH  - Cell Adhesion
MH  - *Cell Adhesion Molecules/metabolism
MH  - Humans
MH  - Integrins/metabolism
MH  - *Neoplasms
MH  - Tumor Microenvironment
PMC - PMC9021432
OTO - NOTNLM
OT  - cell adhesion molecules
OT  - cell adhesion-mediated drug resistance
OT  - chemoresistance
OT  - endocrine-related cancers
OT  - tumor microenvironment
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/26 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/01/01
CRDT- 2022/04/25 05:27
PHST- 2022/01/29 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/25 05:27 [entrez]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.865436 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Apr 7;13:865436. doi: 
      10.3389/fendo.2022.865436. eCollection 2022.