PMID- 35465285
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2223-8956 (Electronic)
IS  - 1016-3190 (Print)
IS  - 1016-3190 (Linking)
VI  - 34
IP  - 2
DP  - 2022 Apr-Jun
TI  - Emerging role of the itaconate-mediated rescue of cellular metabolic stress.
PG  - 134-138
LID - 10.4103/tcmj.tcmj_79_21 [doi]
AB  - Metabolic regulations play vital roles on maintaining the homeostasis of our 
      body. Evidence have suggested that ATF3 and nuclear factor erythroid 2-related 
      factor 2 (NRF2) are critical for maintaining cell function, metabolism, and 
      inflammation/anti-inflammation regulations when cells are under stress, while the 
      upstream regulators in the stressed cells remain elusive. Recent findings have 
      shown that tricarboxylic acid cycle metabolites such as itaconate and succinate 
      are not just mitochondrial metabolites, but rather important signaling mediators, 
      involving in the regulations of metabolism, immune modulation. Itaconate exerts 
      anti-inflammatory role through regulating ATF3 and NRF2 pathways under stressed 
      conditions. In addition, itaconate inhibits succinate dehydrogenase, succinate 
      oxidation and thus blocking succinate-mediated inflammatory processes. These 
      findings suggest itaconate-ATF3 and itaconate-NRF2 axes are well-coordinated 
      machineries that facilitate the rescue against cellular stress. Here, we review 
      these fascinating discoveries, a research field may help the development of more 
      effective therapeutic approach to manage stress-induced inflammation, tissue 
      damage, and metabolic disorder.
CI  - Copyright: (c) 2021 Tzu Chi Medical Journal.
FAU - Sun, Der-Shan
AU  - Sun DS
AD  - Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Chang, Hsin-Hou
AU  - Chang HH
AD  - Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, 
      Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210901
PL  - India
TA  - Tzu Chi Med J
JT  - Tzu chi medical journal
JID - 101770275
PMC - PMC9020237
OTO - NOTNLM
OT  - ATF3
OT  - Inflammasome
OT  - Itaconate
OT  - Mitochondrial stress
OT  - Nuclear factor erythroid 2-related factor 2
COIS- Prof. Hsin-Hou Chang, an editorial board member at Tzu Chi Medical Journal, had 
      no role in the peer review process of or decision to publish this article. The 
      other author declared no conflicts of interest in writing this paper.
EDAT- 2022/04/26 06:00
MHDA- 2022/04/26 06:01
PMCR- 2021/09/01
CRDT- 2022/04/25 05:48
PHST- 2021/03/23 00:00 [received]
PHST- 2021/04/23 00:00 [revised]
PHST- 2021/05/14 00:00 [accepted]
PHST- 2022/04/25 05:48 [entrez]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/04/26 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - TCMJ-34-134 [pii]
AID - 10.4103/tcmj.tcmj_79_21 [doi]
PST - epublish
SO  - Tzu Chi Med J. 2021 Sep 1;34(2):134-138. doi: 10.4103/tcmj.tcmj_79_21. 
      eCollection 2022 Apr-Jun.