PMID- 35465705
OWN - NLM
STAT- MEDLINE
DCOM- 20230727
LR  - 20230727
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 74
IP  - 1
DP  - 2023 Jan
TI  - Effects of Infra-malleolar Status According to Global Limb Anatomic Staging 
      System on Clinical Outcomes in Patients With Chronic Limb-Threatening Ischemia.
PG  - 79-87
LID - 10.1177/00033197221091642 [doi]
AB  - The global vascular guideline proposed a novel anatomical classification of 
      infra-malleolar (IM) arterial lesions. We aimed to investigate the association of 
      IM classification with clinical outcomes in patients with chronic 
      limb-threatening ischemia (CLTI) due to isolated infrapopliteal (IP) lesions. We 
      retrospectively analyzed 509 limbs with tissue loss in 357 patients due to 
      isolated IP lesions who underwent endovascular therapy (EVT) between April 2010 
      and December 2018. The primary outcome was 1-year wound healing rate. The 
      association of patient and anatomic characteristics with non-healing was 
      evaluated using Cox proportional hazards regression analysis. The 1-year 
      cumulative wound healing rate was 59.7%. Multivariable analysis demonstrated that 
      IM grade 2 (hazard ratio [HR], 1.41; P = .044), non-ambulatory status (HR, 1.49; 
      P = .008), hemodialysis (HR, 1.37; P = .020), left ventricular ejection fraction 
      < 50% (HR, 1.72; P = .030), and wound, ischemia, and foot infection (WIfI) 
      classification 4 (HR, 1.33; P = .032) were significantly associated with 
      non-healing, whereas no below-the-ankle (BTA), below-the-knee (BTK) runoff, and 
      Global Limb Anatomic Staging System (GLASS) IP grade had no statistically 
      significant association with non-healing. Global Limb Anatomic Staging System IM 
      grade 2 was an independent risk factor for wound healing in patients who 
      underwent EVT with CLTI due to isolated IP disease.
FAU - Toyoshima, Taku
AU  - Toyoshima T
AUID- ORCID: 0000-0003-1590-5227
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Iida, Osamu
AU  - Iida O
AUID- ORCID: 0000-0001-6829-7304
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Hata, Yosuke
AU  - Hata Y
AUID- ORCID: 0000-0001-5482-3502
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Okamoto, Shin
AU  - Okamoto S
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Ishihara, Takayuki
AU  - Ishihara T
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Nanto, Kiyonori
AU  - Nanto K
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Tsujimura, Takuya
AU  - Tsujimura T
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Higashino, Naoko
AU  - Higashino N
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine and Department of Metabolic Medicine, Osaka 
      University Graduate School of Medicine, Suita, Osaka, Japan.
FAU - Mano, Toshiaki
AU  - Mano T
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220423
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - Humans
MH  - Chronic Limb-Threatening Ischemia
MH  - Treatment Outcome
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - *Peripheral Arterial Disease
MH  - Limb Salvage
MH  - Amputation, Surgical
MH  - Ventricular Function, Left
MH  - Risk Factors
MH  - Ischemia/surgery
MH  - *Endovascular Procedures/adverse effects
OTO - NOTNLM
OT  - angiography
OT  - endovascular therapy
OT  - peripheral arterial disease
EDAT- 2022/04/26 06:00
MHDA- 2023/07/27 06:42
CRDT- 2022/04/25 05:54
PHST- 2023/07/27 06:42 [medline]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/04/25 05:54 [entrez]
AID - 10.1177/00033197221091642 [doi]
PST - ppublish
SO  - Angiology. 2023 Jan;74(1):79-87. doi: 10.1177/00033197221091642. Epub 2022 Apr 
      23.