PMID- 35466169
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230106
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 61
IP  - 23
DP  - 2022 Dec 1
TI  - Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin.
PG  - 3559-3562
LID - 10.2169/internalmedicine.9304-21 [doi]
AB  - A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb 
      lung with thickened walls on chest high-resolution computed tomography (HRCT) and 
      predominance of neutrophils in the cell fraction of the bronchoalveolar lavage 
      fluid. Although there were no centrilobular nodular or branching shadows on chest 
      HRCT suggestive of diffuse panbronchiolitis, he exhibited sinusitis and had the 
      human leukocyte antigen (HLA)-B54 antigen. With long-term macrolide therapy, the 
      cough and sputum production markedly improved, wall thickening of the honeycomb 
      lung on chest HRCT decreased, and the forced vital capacity increased. Confirming 
      the presence of HLA-B54 antigen may help determine the indication for long-term 
      macrolide therapy in interstitial pneumonia patients.
FAU - Ishimoto, Hiroshi
AU  - Ishimoto H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Sakamoto, Noriho
AU  - Sakamoto N
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Hara, Atsuko
AU  - Hara A
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Kido, Takashi
AU  - Kido T
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Yamaguchi, Hiroyuki
AU  - Yamaguchi H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Yamamoto, Kazuko
AU  - Yamamoto K
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Obase, Yasushi
AU  - Obase Y
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
FAU - Ishimatsu, Yuji
AU  - Ishimatsu Y
AD  - Department of Nursing, Nagasaki University Graduate School of Biomedical 
      Sciences, Japan.
FAU - Mukae, Hiroshi
AU  - Mukae H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220423
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 63937KV33D (Erythromycin)
RN  - 0 (HLA-B54 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Macrolides)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - *Erythromycin/pharmacology/therapeutic use
MH  - *Lung Diseases, Interstitial/diagnostic imaging/drug therapy
MH  - HLA-B Antigens
MH  - Macrolides
MH  - Anti-Bacterial Agents/therapeutic use
PMC - PMC9790779
OTO - NOTNLM
OT  - HLA-B54 antigen
OT  - diffuse panbronchiolitis
OT  - erythromycin
OT  - interstitial pneumonia
OT  - macrolide
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2022/04/26 06:00
MHDA- 2022/12/03 06:00
PMCR- 2022/12/01
CRDT- 2022/04/25 06:14
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/04/25 06:14 [entrez]
PHST- 2022/12/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.9304-21 [doi]
PST - ppublish
SO  - Intern Med. 2022 Dec 1;61(23):3559-3562. doi: 10.2169/internalmedicine.9304-21. 
      Epub 2022 Apr 23.