PMID- 35466550
OWN - NLM
STAT- MEDLINE
DCOM- 20220630
LR  - 20220630
IS  - 1864-564X (Electronic)
IS  - 1864-5631 (Linking)
VI  - 15
IP  - 12
DP  - 2022 Jun 22
TI  - Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts 
      with Complete Atom Economy.
PG  - e202200529
LID - 10.1002/cssc.202200529 [doi]
AB  - A solvent-free method for the synthesis of quaternary ammonium salts (QAS) by 
      iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages 
      lie in energy-saving and clean production by using iodine as the oxidant and 
      manual grinding the starting materials, together with the complete atom economy 
      and low process mass intensity (PMI) value. Demonstrated by 50 examples, the 
      generated QAS was proved to be able to produce valuable chemicals, such as 
      biological protease inhibitors, anti-cancer agents, and organic fluorescent 
      materials.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Fan, Weibin
AU  - Fan W
AD  - State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the 
      Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. 
      China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the 
      Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. 
      China.
FAU - Li, Yinghua
AU  - Li Y
AD  - State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the 
      Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. 
      China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the 
      Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. 
      China.
FAU - Huang, Deguang
AU  - Huang D
AUID- ORCID: 0000-0002-9034-2842
AD  - State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the 
      Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. 
      China.
LA  - eng
GR  - 21371171/National Natural Science Foundation of China/
GR  - XDB20000000/Chinese Academy of Sciences/
GR  - 2020J01114/Natural Science Foundation of Fujian Province/
PT  - Journal Article
DEP - 20220516
PL  - Germany
TA  - ChemSusChem
JT  - ChemSusChem
JID - 101319536
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Salts)
RN  - 0 (Solvents)
SB  - IM
MH  - *Quaternary Ammonium Compounds/pharmacology
MH  - *Salts
MH  - Solvents
OTO - NOTNLM
OT  - atom economy
OT  - mechanochemistry
OT  - organic chemistry
OT  - pyridinium
OT  - solvent-free
EDAT- 2022/04/26 06:00
MHDA- 2022/07/01 06:00
CRDT- 2022/04/25 06:17
PHST- 2022/04/22 00:00 [revised]
PHST- 2022/03/13 00:00 [received]
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/07/01 06:00 [medline]
PHST- 2022/04/25 06:17 [entrez]
AID - 10.1002/cssc.202200529 [doi]
PST - ppublish
SO  - ChemSusChem. 2022 Jun 22;15(12):e202200529. doi: 10.1002/cssc.202200529. Epub 
      2022 May 16.