PMID- 35468038
OWN - NLM
STAT- MEDLINE
DCOM- 20221118
LR  - 20230428
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 18
IP  - 12
DP  - 2022 Dec
TI  - Intrinsic role of chaperone-mediated autophagy in cancer stem cell maintenance.
PG  - 3035-3036
LID - 10.1080/15548627.2022.2069450 [doi]
AB  - Chaperone-mediated autophagy (CMA) is a selective type of autophagy specialized 
      in the individual degradation of targeted proteins. Its impact in any cancer stem 
      cell (CSC) subtype remained elusive. In a recent study, we characterized the 
      expression of LAMP2A and CMA activity in glioblastoma revealing its enrichment in 
      a glioma stem cell (GSC) subpopulation. LAMP2A downregulation diminishes 
      proliferation and self-renewal and induces apoptosis in GSCs in vitro, whereas it 
      delays tumor progression in vivo. The underlying molecular signature of CMA 
      comprises several proteomic and transcriptomic pathways with special relevance to 
      mitochondrial function, the interferon pathway and extracellular matrix 
      interactions. Remarkably, these activities are translated into the clinical 
      scenario, as glioblastoma (GBM) samples show increased expression of LAMP2 
      compared to healthy tissue, with this expression being positively associated with 
      malignancy grade, TMZ resistance and lower patient survival. These results reveal 
      a novel function of CMA as an intrinsic regulator of GSC tumorigenic properties 
      and highlight its relevance in GBM progression.
FAU - Auzmendi-Iriarte, Jaione
AU  - Auzmendi-Iriarte J
AD  - Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, 
      Spain.
FAU - Matheu, Ander
AU  - Matheu A
AD  - Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, 
      Spain.
AD  - CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain.
AD  - IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220427
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
SB  - IM
MH  - Humans
MH  - *Glioblastoma/metabolism
MH  - *Chaperone-Mediated Autophagy
MH  - Autophagy
MH  - Cell Line, Tumor
MH  - Proteomics
MH  - Neoplastic Stem Cells/pathology
PMC - PMC9673963
OTO - NOTNLM
OT  - CMA
OT  - Cancer stem cell
OT  - LAMP2A
OT  - glioblastoma
OT  - proteomic and transcriptomic analysis
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2022/04/26 06:00
MHDA- 2022/11/19 06:00
PMCR- 2023/04/27
CRDT- 2022/04/25 17:24
PHST- 2022/04/26 06:00 [pubmed]
PHST- 2022/11/19 06:00 [medline]
PHST- 2022/04/25 17:24 [entrez]
PHST- 2023/04/27 00:00 [pmc-release]
AID - 2069450 [pii]
AID - 10.1080/15548627.2022.2069450 [doi]
PST - ppublish
SO  - Autophagy. 2022 Dec;18(12):3035-3036. doi: 10.1080/15548627.2022.2069450. Epub 
      2022 Apr 27.