PMID- 35468408 OWN - NLM STAT- MEDLINE DCOM- 20220524 LR - 20220624 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 164 DP - 2022 Jun TI - Associations of urinary perchlorate, nitrate and thiocyanate with central sensitivity to thyroid hormones: A US population-based cross-sectional study. PG - 107249 LID - S0160-4120(22)00175-1 [pii] LID - 10.1016/j.envint.2022.107249 [doi] AB - BACKGROUND: Perchlorate, nitrate, and thiocyanate are three well-known sodium iodine symporter inhibitors, however, associations of their individual and concurrent exposure with central thyroid hormones sensitivity remain unclear. OBJECTIVES: To investigate the associations of urinary perchlorate, nitrate, thiocyanate, and their co-occurrence with central thyroid hormones sensitivity among US general adults. METHODS: A total of 7598 non-pregnant adults (weighted mean age 45.9 years and 52.9% men) from National Health and Nutritional Examination Survey 2007-2012 were included in this cross-sectional study. Central sensitivity to thyroid hormones was estimated with the Parametric Thyroid Feedback Quantile-based Index (PTFQI). Ordinary least-squares regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models were performed to examine the associations of three anions and their co-occurrence with PTFQI. RESULTS: The weighted mean values of urinary perchlorate, nitrate, thiocyanate, and perchlorate equivalent concentration (PEC) were 5.48 mug/L, 57.59 mg/L, 2.65 mg/L, and 539.8 mug/L, respectively. Compared with the lowest quartile, the least-square means difference (LSMD) of PTFQI was -0.0516 (LSMD +/- SE: -0.0516 +/- 0.0185, P < 0.01) in the highest perchlorate quartile. On average, PTFQI decreased by 0.0793 (LSMD +/- SE: -0.0793 +/- 0.0205, P < 0.001) between the highest and lowest thiocyanate quartile. Compared with those in the lowest quartile, participants in the highest PEC quartile had significantly decreased PTFQI levels (LSMD +/- SE: -0.0862 +/- 0.0188, P < 0.001). The WQS of three goitrogens, was inversely associated with PTFQI (beta: -0.051, 95% CI: -0.068, -0.034). In BKMR model, PTFQI significantly decreased when the levels of three anions were at or above their 60th percentiles compared to the median values. CONCLUSIONS: Higher levels of urinary perchlorate, thiocyanate, and co-occurrence of three goitrogens were associated with increased central thyroid hormones sensitivity among US general adults. Further studies are warranted to replicate our results and elucidate the underlying causative mechanistic links. CI - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - King, Lei AU - King L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Huang, Yue AU - Huang Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Li, Tao AU - Li T AD - Institute of Statistics and Big Data, Renmin University of China, Beijing, China. FAU - Wang, Qiang AU - Wang Q AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Li, Wanyi AU - Li W AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Shan, Zhilei AU - Shan Z AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Yin, Jiawei AU - Yin J AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Chen, Liangkai AU - Chen L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Pei AU - Wang P AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Dun, Changchang AU - Dun C AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhuang, Litao AU - Zhuang L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Peng, Xiaolin AU - Peng X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. Electronic address: xiaolinpeng@hotmail.com. FAU - Liu, Liegang AU - Liu L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: lgliu@mails.tjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220420 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Antithyroid Agents) RN - 0 (Nitrates) RN - 0 (Nitrogen Oxides) RN - 0 (Perchlorates) RN - 0 (Thiocyanates) RN - 0 (Thyroid Hormones) SB - IM MH - Adult MH - Antithyroid Agents MH - Bayes Theorem MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Middle Aged MH - Nitrates MH - Nitrogen Oxides MH - *Perchlorates MH - *Thiocyanates MH - Thyroid Hormones OTO - NOTNLM OT - National Health and Nutrition Examination Survey OT - Nitrate OT - Perchlorate OT - Thiocyanate OT - Thyroid hormones sensitivity EDAT- 2022/04/26 06:00 MHDA- 2022/05/25 06:00 CRDT- 2022/04/25 20:16 PHST- 2021/07/12 00:00 [received] PHST- 2022/03/10 00:00 [revised] PHST- 2022/04/13 00:00 [accepted] PHST- 2022/04/26 06:00 [pubmed] PHST- 2022/05/25 06:00 [medline] PHST- 2022/04/25 20:16 [entrez] AID - S0160-4120(22)00175-1 [pii] AID - 10.1016/j.envint.2022.107249 [doi] PST - ppublish SO - Environ Int. 2022 Jun;164:107249. doi: 10.1016/j.envint.2022.107249. Epub 2022 Apr 20.