PMID- 35469665
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20220713
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 77
IP  - 7
DP  - 2022 Jul
TI  - Evaluation of articular cartilage in knee osteoarthritis using hybrid 
      multidimensional MRI.
PG  - e518-e525
LID - S0009-9260(22)00135-0 [pii]
LID - 10.1016/j.crad.2022.03.002 [doi]
AB  - AIM: To evaluate a two-compartment model with a normal and an abnormal 
      compartment using hybrid multidimensional (HM) magnetic resonance imaging (MRI) 
      for detection of early stage degeneration in knee articular cartilage. MATERIALS 
      AND METHODS: Forty mild osteoarthritis (OA; Kellgren-Lawrence grades [KLGs] 1 and 
      2), 27 moderate OA (KLG 3), and 23 healthy controls were included in the study. 
      HM imaging using a two-compartment model was used to measure a normal and an 
      abnormal cartilage compartment. The relationship between V(normal) and the degree 
      of cartilage degeneration was examined using whole-organ MRI scores (WORMS). 
      Receiver operating characteristic analysis was used to detect the ability of 
      V(normal), apparent diffusion coefficient (ADC), and T2 relaxation time to 
      discriminate healthy controls from early OA. RESULTS: The intra- and 
      interobserver reproducibility for calculated mean V(normal) values and WORMS 
      indicated substantial agreement (intraclass correlation coefficient and weighted 
      kappa >0.8). Overall, V(normal) in all compartments significantly differed among 
      the healthy controls (50 +/- 5.5%) and mild (41.1 +/- 5.3%) and moderate OA 
      (36.4 +/- 8.1%). Mean V(normal) correlated negatively with the degree of OA 
      progression (rho = -0.778, p<0.001). Mean V(normal) was characterised by a higher 
      sensitivity (82.5%, 95% confidence interval [CI = 67.2-92.7) and specificity 
      (87%, 95% CI = 66.4-97.2), with a cut-off value of 44.4%, compared to ADC and T2 
      values or a combination of ADC and T2 to differentiate early OA from healthy 
      controls. CONCLUSIONS: HM-MRI coupled with values of ADC and T2 may provide value 
      for detecting cartilage degeneration at an early stage of OA.
CI  - Copyright (c) 2022 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Luo, P
AU  - Luo P
AD  - Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 
      200437, China.
FAU - Hu, W
AU  - Hu W
AD  - Central Research Institute, United Imaging Healthcare, Shanghai, 201807, China.
FAU - Jiang, L
AU  - Jiang L
AD  - Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 
      200437, China.
FAU - Chang, S
AU  - Chang S
AD  - Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 
      200437, China.
FAU - Wu, D
AU  - Wu D
AD  - Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronics 
      Science, East China Normal University, Shanghai, 200062, China. Electronic 
      address: dmwu@phy.ecnu.edu.cn.
FAU - Li, G
AU  - Li G
AD  - Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and 
      Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 
      200437, China. Electronic address: purenyi@163.com.
FAU - Dai, Y
AU  - Dai Y
AD  - Central Research Institute, United Imaging Healthcare, Shanghai, 201807, China.
LA  - eng
PT  - Journal Article
DEP - 20220424
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - *Cartilage Diseases/pathology
MH  - *Cartilage, Articular/diagnostic imaging/pathology
MH  - Humans
MH  - Knee Joint/pathology
MH  - Magnetic Resonance Imaging/methods
MH  - *Osteoarthritis, Knee/diagnostic imaging
MH  - Reproducibility of Results
EDAT- 2022/04/27 06:00
MHDA- 2022/06/16 06:00
CRDT- 2022/04/26 05:55
PHST- 2021/12/08 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2022/04/26 05:55 [entrez]
AID - S0009-9260(22)00135-0 [pii]
AID - 10.1016/j.crad.2022.03.002 [doi]
PST - ppublish
SO  - Clin Radiol. 2022 Jul;77(7):e518-e525. doi: 10.1016/j.crad.2022.03.002. Epub 2022 
      Apr 24.