PMID- 35469855
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220723
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 212
IP  - Pt B
DP  - 2022 Sep
TI  - Associations between environmental exposure to polybrominated diphenyl ethers and 
      nodular goiter risk: A case-control study.
PG  - 113345
LID - S0013-9351(22)00672-7 [pii]
LID - 10.1016/j.envres.2022.113345 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are widespread and persistent 
      environmental contaminants, but their association with nodular goiter (NG) 
      remains unknown. The present case-control study of 179 NG cases and 358 matched 
      normal controls aimed to investigate the association between PBDEs and risk of 
      NG. The plasma concentrations of 8 PBDEs congeners (BDE-28, -47, -99, -100, -153, 
      -154, -183, and -209) were determined by gas chromatograph-mass spectrometer. 
      Conditional logistic regression model was used to evaluate the odds ratio (OR) 
      and 95% confidence interval (CI) for the association between each PBDEs congener 
      and NG. Bayesian kernel machine regression (BKMR) was used to evaluate the 
      association between overall levels of 8 PBDEs mixture and NG. The results of 
      logistic model suggested that increased risk of NG was associated with elevated 
      concentrations of all PBDEs congeners, except for BDE-209. In BKMR model, the 
      risk of NG increased with the increase in overall exposure level of 8 PBDEs 
      mixture. Compared to when all PBDEs mixture were at their median value, the risk 
      of exposure-response function for NG increased by 0.34 units when all PBDEs were 
      at their 75th percentile. In women, the results showed similar trends after 
      additional adjustment for age at menarche and menopausal status. These findings 
      provide novel epidemiological evidence for the prevention of NG. However, larger 
      prospective studies are required to address the associations between PBDEs 
      exposure and NG risk.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Hu, Ming-Jun
AU  - Hu MJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, 230032, China.
FAU - Wang, Sheng
AU  - Wang S
AD  - The Center for Scientific Research of Anhui Medical University, Hefei, Anhui, 
      230032, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, Fujian, 350122, China.
FAU - He, Jia-Liu
AU  - He JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, 230032, China.
FAU - Zhao, Huan-Huan
AU  - Zhao HH
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, 230032, China.
FAU - Hu, Wen-Lei
AU  - Hu WL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, 230032, China.
FAU - Huang, Fen
AU  - Huang F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, 230032, China; Key Laboratory for Environmental 
      Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 
      Anhui, 230032, China. Electronic address: fenh@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220422
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - China
MH  - Environmental Exposure/analysis
MH  - Environmental Monitoring
MH  - Female
MH  - *Goiter, Nodular
MH  - *Halogenated Diphenyl Ethers/analysis
MH  - Humans
OTO - NOTNLM
OT  - BKMR analysis
OT  - NG
OT  - PBDEs
OT  - Risk factor
EDAT- 2022/04/27 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/04/26 05:57
PHST- 2022/03/18 00:00 [received]
PHST- 2022/04/18 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/04/26 05:57 [entrez]
AID - S0013-9351(22)00672-7 [pii]
AID - 10.1016/j.envres.2022.113345 [doi]
PST - ppublish
SO  - Environ Res. 2022 Sep;212(Pt B):113345. doi: 10.1016/j.envres.2022.113345. Epub 
      2022 Apr 22.