PMID- 35471164
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 63
IP  - 27
DP  - 2023
TI  - Dietary fiber in the prevention of obesity and obesity-related chronic diseases: 
      From epidemiological evidence to potential molecular mechanisms.
PG  - 8752-8767
LID - 10.1080/10408398.2022.2061909 [doi]
AB  - Obesity is a mostly preventable diet-related disease and currently a major 
      challenge for human populations worldwide. Obesity is a major risk factor for 
      diseases such as type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) 
      and certain cancers. Dietary fiber is a complex mixture of non-digestible 
      molecules, mostly polysaccharides. Multiple epidemiological studies have 
      demonstrated statistically significant reductions in risks of obesity, T2DM, CVD, 
      colorectal cancer, and pre-menopausal breast cancer with higher dietary fiber 
      intakes. Various direct and indirect mechanisms have been proposed including 
      altered digestion and absorption, stimulation of gut hormones including 
      glucagon-like-peptide-1 (GLP-1) and peptide YY (PYY), reduced appetite, and 
      altered metabolism of bile and cholesterol. These may act via pathways involving 
      G-protein-coupled receptors (GPRs), histone deacetylase (HDAC), and aromatase 
      enzymes. Ultimately, fiber intake contributes to improving glucose levels and 
      insulin sensitivity, lowering risk of T2DM, CVD and certain cancers. Therefore, 
      diets rich in dietary fiber should be encouraged to prevent obesity and 
      associated chronic disease.
FAU - Waddell, Isabella Skye
AU  - Waddell IS
AD  - School of Food Science and Nutrition, Woodhouse Lane, University of Leeds, Leeds, 
      UK.
FAU - Orfila, Caroline
AU  - Orfila C
AUID- ORCID: 0000-0003-2564-8068
AD  - School of Food Science and Nutrition, Woodhouse Lane, University of Leeds, Leeds, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20220426
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/prevention & control
MH  - Obesity/complications/epidemiology/prevention & control
MH  - Dietary Fiber/metabolism
MH  - *Cardiovascular Diseases/epidemiology/prevention & control
MH  - *Neoplasms
OTO - NOTNLM
OT  - Dietary fiber
OT  - dietary fiber
OT  - microbiome
OT  - microbiota
OT  - non-communicable diseases
OT  - obesity
OT  - short chain fatty acids
EDAT- 2022/04/27 06:00
MHDA- 2023/11/02 12:46
CRDT- 2022/04/26 12:09
PHST- 2023/11/02 12:46 [medline]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/04/26 12:09 [entrez]
AID - 10.1080/10408398.2022.2061909 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2023;63(27):8752-8767. doi: 
      10.1080/10408398.2022.2061909. Epub 2022 Apr 26.