PMID- 35472355
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20221227
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 835
DP  - 2022 Aug 20
TI  - A pilot evaluation on the toxicokinetics and bioaccumulation of polychlorinated 
      naphthalenes in laying hens.
PG  - 155454
LID - S0048-9697(22)02548-7 [pii]
LID - 10.1016/j.scitotenv.2022.155454 [doi]
AB  - Knowledge of the transfer features of polychlorinated naphthalenes (PCNs), a 
      class of emerging persistent organic pollutants (POPs), is still lacking 
      concerning the environment-feed-food transfer chain of farm animals. We conducted 
      a controlled feeding experiment with laying hens fed fly ash-contaminated diets 
      to investigate the toxicokinetics and bioaccumulation of PCNs (tri- to octa-CNs) 
      in the hen eggs and tissues. The eggs showed increasing PCNs levels after 14 days 
      of oral exposure, which gradually decreased during the 28-day depuration period 
      but still exceeded the initial levels. The apparent one-compartment half-life of 
       summation operator(63)PCNs in the eggs was 28.9 days, which was comparable to those of other 
      dioxin-like compounds. The uptake and depuration rates of PCN congeners in the 
      eggs were 0.002-0.010 and 0.016-0.079 days(-1) in eggs, respectively. The 
      depuration rates were decreased with the n-octanol/water partition coefficients 
      (logK(OW)), indicating that the eggs retained more lipophilic congeners, whereas 
      the uptake rates increased with the logK(OW), indicating the faster deposition of 
      the more lipophilic PCNs in eggs during the exposure period. The transfer rates 
      of PCN congeners ranged from 0.27%-23.0%, indicating the transfer potential of 
      PCNs from feed to eggs. Additionally, the PCN distribution in the laying hens at 
      the end of the exposure showed tissue-specific accumulation, with the high levels 
      of PCNs in the liver, spleen, and ovum. Positive correlations between the 
      transfer factors (C(tissue)/C(feed)) and the logK(OW) suggested that more 
      lipophilic PCN congeners tended to accumulate in the tissues. After 
      quantitatively assessing the feed-to-food transfer of PCNs in laying hens, our 
      results highlight the risk of exposure to PCNs in the food supply chain.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Chu
AU  - Wang C
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China; Sino-Danish College, University of Chinese Academy of Sciences, 
      Beijing 100049, China.
FAU - Dong, Shujun
AU  - Dong S
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: 
      dongshujun@caas.cn.
FAU - Wang, Pu
AU  - Wang P
AD  - Hubei Key Laboratory of Industrial Fume and Dust Pollution Control, School of 
      Environment and Health, Jianghan University, Wuhan 430056, China.
FAU - Hao, Yanfen
AU  - Hao Y
AD  - Hubei Key Laboratory of Industrial Fume and Dust Pollution Control, School of 
      Environment and Health, Jianghan University, Wuhan 430056, China.
FAU - Wang, Ruiguo
AU  - Wang R
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China.
FAU - Zhang, Su
AU  - Zhang S
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China.
FAU - Wang, Yaxin
AU  - Wang Y
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China.
FAU - Wang, Peilong
AU  - Wang P
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Chinese 
      Academy of Agricultural Sciences, Beijing 100081, China.
FAU - Zhang, Qinghua
AU  - Zhang Q
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China; Sino-Danish College, University of Chinese Academy of Sciences, 
      Beijing 100049, China; School of Environment, Hangzhou Institute for Advanced 
      Study, University of Chinese Academy of Sciences, Hangzhou 310000, China.
FAU - Jiang, Guibin
AU  - Jiang G
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
LA  - eng
PT  - Journal Article
DEP - 20220423
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Dioxins)
RN  - 0 (Naphthalenes)
SB  - IM
MH  - Animals
MH  - Female
MH  - Bioaccumulation
MH  - *Chickens
MH  - *Dioxins
MH  - Naphthalenes
MH  - Pilot Projects
MH  - Toxicokinetics
OTO - NOTNLM
OT  - Depuration
OT  - Polychlorinated naphthalene
OT  - Tissue distribution
OT  - Transfer rate
OT  - Uptake
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/04/27 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/04/26 20:03
PHST- 2022/01/28 00:00 [received]
PHST- 2022/04/15 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/04/26 20:03 [entrez]
AID - S0048-9697(22)02548-7 [pii]
AID - 10.1016/j.scitotenv.2022.155454 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Aug 20;835:155454. doi: 10.1016/j.scitotenv.2022.155454. 
      Epub 2022 Apr 23.