PMID- 35472511
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220517
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 620
DP  - 2022 May 25
TI  - Optimization of large-scale manufacturing of biopolymeric and lipid nanoparticles 
      using microfluidic swirl mixers.
PG  - 121762
LID - S0378-5173(22)00317-9 [pii]
LID - 10.1016/j.ijpharm.2022.121762 [doi]
AB  - Nanoparticles (NPs) have great potential as efficient drug delivery systems 
      (DDSs) that have been widely used in cancer therapy and vaccines especially in 
      the past decade. The rise in demand from the pharmaceutical industry drives the 
      growth of the global NPs market. However, complex production processes have 
      hindered the market growth. Therefore, the development of advanced preparation 
      techniques such as microfluidics is required to improve productivity and 
      controllability. In this study, we present a novel microfluidic design (swirl 
      mixer) that helps accelerating the translation of many DDSs from laboratory to 
      clinical application. The new swirl mixer provides high production rate, 
      reproducibility, and precise control of particle size with low polydispersity 
      index (PDI). To assess the performance of the swirl mixer, two different types of 
      nanoformulations were used: silk nanoparticles (SNPs) and lipid nanoparticles 
      (LNPs). The microfluidic device produced NPs efficiently with high productivity 
      and allowed for tuning the mean size and size distribution by changing multiple 
      processing parameters.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Tomeh, Mhd Anas
AU  - Tomeh MA
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK.
FAU - Mansor, Muhamad Hawari
AU  - Mansor MH
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK.
FAU - Hadianamrei, Roja
AU  - Hadianamrei R
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK.
FAU - Sun, Weizhen
AU  - Sun W
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK.
FAU - Zhao, Xiubo
AU  - Zhao X
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK; School of Pharmacy, Changzhou University, Changzhou 213164, 
      China. Electronic address: xiubo.zhao@cczu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220423
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Lipid Nanoparticles)
RN  - 0 (Liposomes)
SB  - IM
MH  - Liposomes
MH  - *Microfluidics/methods
MH  - *Nanoparticles
MH  - Particle Size
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Doxorubicin
OT  - Drug delivery
OT  - Lipid nanoparticles
OT  - Microfluidic
OT  - Nanoparticle manufacturing
OT  - Silk fibroin
OT  - Swirl mixer
EDAT- 2022/04/27 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/04/26 20:06
PHST- 2022/01/01 00:00 [received]
PHST- 2022/04/18 00:00 [revised]
PHST- 2022/04/20 00:00 [accepted]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/26 20:06 [entrez]
AID - S0378-5173(22)00317-9 [pii]
AID - 10.1016/j.ijpharm.2022.121762 [doi]
PST - ppublish
SO  - Int J Pharm. 2022 May 25;620:121762. doi: 10.1016/j.ijpharm.2022.121762. Epub 
      2022 Apr 23.