PMID- 35472833
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20220627
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 151
DP  - 2022 Jun
TI  - Systemic and ovarian inflammation in women with polycystic ovary syndrome.
PG  - 103628
LID - S0165-0378(22)00157-7 [pii]
LID - 10.1016/j.jri.2022.103628 [doi]
AB  - Polycystic ovary syndrome (PCOS) is a common endocrine/reproductive/metabolic 
      disorder. The etiology of PCOS is complex and has been linked to low-grade 
      chronic inflammation. Local inflammation of the ovary affects ovulation and 
      induces or aggravates systemic inflammation. PCOS patients demonstrated 
      significantly higher concentrations of circulating inflammatory cells, such as 
      lymphocytes, neutrophils, eosinophilic granulocytes, monocytes and Th17 cells 
      than women without PCOS, while the percentage of Treg cells was lower. 
      Inflammatory factors, such as serum CRP, hs-CRP, IL-1Ra, IL-6, IL-17A, IL-17F, 
      IL-18, IL-23, TNF-alpha, alpha-1 acid glycoprotein,monocyte chemoattractant protein-1 
      (MCP-1) and adipokines and their paralogs, including chemerin, C1q and 
      TNF-related 6 (C1QTNF6), were also found to be significantly increased in the 
      peripheral blood of PCOS patients. Levels of anti-inflammatory cytokines, such as 
      IL-10, IL-17E, IL-27, IL-35 and IL-37, TGF-beta, omentin-1, Secreted 
      frizzled-related protein5 (SFRP5) were significantly lower. An analogous 
      situation occurs locally in the ovary. Some vital inflammatory cells and 
      cytokines may initially be released from the ovary and then enter the 
      circulation. The systemic inflammation underlying PCOS is thought to interact 
      with obesity, insulin resistance (IR) and hyperandrogenism. Traditional Chinese 
      medicine, multitargeted treatment, anti-inflammatory and antioxidant medicine, 
      and lifestyle modification can benefit PCOS women by alleviating inflammatory 
      responses.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Zhai, Yi
AU  - Zhai Y
AD  - Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking 
      University Third Hospital, Beijing 100191, China; National Clinical Research 
      Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 
      100191, China; Key Laboratory of Assisted Reproduction (Peking University), 
      Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of 
      Reproductive Endocrinology and Assisted Reproductive Technology (Peking 
      University Third Hospital), Beijing 100191, China.
FAU - Pang, Yanli
AU  - Pang Y
AD  - Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking 
      University Third Hospital, Beijing 100191, China; National Clinical Research 
      Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 
      100191, China; Key Laboratory of Assisted Reproduction (Peking University), 
      Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of 
      Reproductive Endocrinology and Assisted Reproductive Technology (Peking 
      University Third Hospital), Beijing 100191, China. Electronic address: 
      yanlipang@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220416
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (C1qTNF6 protein, human)
RN  - 0 (Cytokines)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Collagen/therapeutic use
MH  - Cytokines
MH  - Female
MH  - Humans
MH  - *Hyperandrogenism
MH  - Inflammation
MH  - *Insulin Resistance
MH  - *Polycystic Ovary Syndrome
OTO - NOTNLM
OT  - Hyperandrogenism
OT  - Inflammation
OT  - Insulin Resistance
OT  - Obesity
OT  - Polycystic Ovary Syndrome
EDAT- 2022/04/27 06:00
MHDA- 2022/05/24 06:00
CRDT- 2022/04/26 20:23
PHST- 2022/02/13 00:00 [received]
PHST- 2022/04/01 00:00 [revised]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/04/27 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PHST- 2022/04/26 20:23 [entrez]
AID - S0165-0378(22)00157-7 [pii]
AID - 10.1016/j.jri.2022.103628 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2022 Jun;151:103628. doi: 10.1016/j.jri.2022.103628. Epub 2022 
      Apr 16.