PMID- 35473698
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20240426
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 15
IP  - 4
DP  - 2022 Apr 26
TI  - Follicular dendritic cell sarcoma of the thigh: a clinicopathological report and 
      management approach.
LID - 10.1136/bcr-2021-244812 [doi]
LID - e244812
AB  - Follicular dendritic cells are antigen-presenting immune accessory cells of 
      mesenchymal origin. Follicular dendritic cell sarcomas (FDCS) typically occur in 
      nodal and extranodal sites. However, presentation in the extremity has rarely 
      been reported. A woman in her 60s had a painless, slow-growing right posterior 
      thigh swelling, which had been present for 9 months. Imaging revealed a 
      subcutaneous lesion in the posterior aspect of the right mid-thigh. Fine-needle 
      aspiration cytology from the lesion was suggestive of a malignant spindle cell 
      neoplasm, and she underwent its wide local excision. Immunohistochemistry showed 
      expression of epithelial membrane antigen and CD35, but an absence of 
      cytokeratin, desmin, CD23 and S100. The Ki-67 index was low and a diagnosis of 
      FDCS was made. The lack of clinical guidelines was a challenge in the treatment 
      of this rare case. A multidisciplinary board discussion played a critical role in 
      the planning of the patient's adjuvant treatment.
CI  - (c) BMJ Publishing Group Limited 2022. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Rajan, Rajasree
AU  - Rajan R
AD  - Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, 
      Cochin, Kerala, India.
FAU - Roshni, Divya Gireesan
AU  - Roshni DG
AD  - Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, 
      Cochin, Kerala, India.
FAU - Mathew, Suzann Mary
AU  - Mathew SM
AD  - Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.
FAU - Jojo, Annie
AU  - Jojo A
AD  - Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India 
      dr.anniejojo@ymail.com.
FAU - Nair, Haridas Mohanachandran
AU  - Nair HM
AD  - Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, 
      Cochin, Kerala, India.
FAU - Kottarathil, Vijayakumar Dehannathparambil
AU  - Kottarathil VD
AD  - Surgical Oncology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220426
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
SB  - IM
MH  - Biopsy, Fine-Needle
MH  - *Dendritic Cell Sarcoma, Follicular/diagnosis/surgery
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - *Sarcoma
MH  - Thigh/pathology
PMC - PMC9045049
OTO - NOTNLM
OT  - Oncology
OT  - Pathology
OT  - Radiotherapy
OT  - Surgery
COIS- Competing interests: None declared.
EDAT- 2022/04/28 06:00
MHDA- 2022/04/29 06:00
PMCR- 2024/04/25
CRDT- 2022/04/27 05:21
PHST- 2022/04/27 05:21 [entrez]
PHST- 2022/04/28 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2024/04/25 00:00 [pmc-release]
AID - 15/4/e244812 [pii]
AID - bcr-2021-244812 [pii]
AID - 10.1136/bcr-2021-244812 [doi]
PST - epublish
SO  - BMJ Case Rep. 2022 Apr 26;15(4):e244812. doi: 10.1136/bcr-2021-244812.