PMID- 35476846
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220624
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 4
DP  - 2022
TI  - Spectral-domain OCT measurements in obesity: A systematic review and 
      meta-analysis.
PG  - e0267495
LID - 10.1371/journal.pone.0267495 [doi]
LID - e0267495
AB  - BACKGROUND: Previous studies proposed possible applications of spectral-domain 
      optical coherence tomography (SD-OCT) measurements in prognosticating pathologies 
      observed in overweight/obesity, including ocular, vascular, and neurologic 
      consequences. Therefore, we conducted a systematic review and meta-analysis to 
      investigate the changes in the in SD-OCT measurements of the patients with higher 
      body mass index (BMI) compared to normal weight individuals. MATERIALS AND 
      METHODS: We conducted a systematic search on PubMed, Scopus, and Embase. The 
      search results underwent two-phase title/abstract and full-text screenings. We 
      then analyzed SD-OCT measurements differences in patients with high BMI and 
      controls, and performed meta-regression, sub-group analysis, quality assessment, 
      and publication bias assessment. The measurements included macular thickness, cup 
      to disc ratio, ganglion cell-inner plexiform layer (GC-IPL) and its sub-sectors, 
      RNFL and peripapillary RNFL (pRNFL) and their sub-layers, and choroidal thickness 
      and its sub-sectors. RESULTS: 19 studies were included in this meta-analysis 
      accounting for 1813 individuals, 989 cases and 824 controls. There was an overall 
      trend towards decreased thickness in high BMI patients, but only two measurements 
      reached statistical significance: temporal retinal nerve fiber layer (RNFL) 
      (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 
      to -0.14, p<0.01) and the choroidal region 1.0 mm nasal to fovea (SMD: -0.38, 95% 
      CI: -0.60 to -0.16, p<0.01). CONCLUSION: Some ocular layers are thinner in 
      patients with higher BMI than the controls. These SD-OCT measurements might 
      correlate with adverse events related to increased body weight and have 
      prognostic abilities. As SD-OCT is a robust, rapid and non-invasive tool, future 
      guidelines and studies are needed to evaluate the possibility of their 
      integration into care of the patients with obesity.
FAU - Salehi, Mohammad Amin
AU  - Salehi MA
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Karimi, Amirali
AU  - Karimi A
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mohammadi, Soheil
AU  - Mohammadi S
AUID- ORCID: 0000-0003-0616-1780
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Arevalo, J Fernando
AU  - Arevalo JF
AD  - Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, 
      United States of America.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220427
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Nerve Fibers/pathology
MH  - Obesity/diagnostic imaging/pathology
MH  - *Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence/methods
PMC - PMC9045631
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/04/28 06:00
MHDA- 2022/04/30 06:00
PMCR- 2022/04/27
CRDT- 2022/04/27 17:17
PHST- 2021/10/06 00:00 [received]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/04/27 17:17 [entrez]
PHST- 2022/04/28 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2022/04/27 00:00 [pmc-release]
AID - PONE-D-21-32203 [pii]
AID - 10.1371/journal.pone.0267495 [doi]
PST - epublish
SO  - PLoS One. 2022 Apr 27;17(4):e0267495. doi: 10.1371/journal.pone.0267495. 
      eCollection 2022.