PMID- 35477378
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220716
IS  - 1471-2482 (Electronic)
IS  - 1471-2482 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Apr 27
TI  - Efficacy of anterior debridement and bone grafting with fusion using internal 
      fixation combined with anti-tuberculosis chemotherapy in the treatment of 
      subaxial cervical tuberculosis.
PG  - 150
LID - 10.1186/s12893-022-01606-y [doi]
LID - 150
AB  - BACKGROUND: To evaluate the efficacy of anterior debridement and bone grafting 
      with fusion using internal fixation (BFIF) combined with anti-tuberculosis 
      chemotherapy in the treatment of subaxial cervical spine tuberculosis (SCS-TB). 
      METHODS: Clinical and radiographic data of patients with SCS-TB treated by 
      anterior debridement and BFIF at our hospital from January 2010 to December 2017 
      were analyzed retrospectively. The SCS sagittal parameters at the preoperative, 
      postoperative, and final follow-up were documented and compared, including the 
      Occiput-C2 angle, C2-C7 Cobb angle, local Cobb angle, spinal canal angle (SCA), 
      C2-C7 sagittal vertical axis (C2-C7 SVA), the center of gravity of the head-C7 
      sagittal vertical axis (CGH-C7 SVA), T1 slope (T1S), neck tilt (NT), and thoracic 
      inlet angle (TIA). The ASIA grade, NDI index, JOA score, and VAS score were 
      utilized to assess the postoperative function recovery, and the complications 
      were recorded. RESULTS: A total of 23 patients were included in the study with a 
      mean age of 46.74 +/- 15.43 years, including 8 males and 15 females. All patients 
      with SCS-TB were treated with anterior debridement and BFIF, with a mean 
      postoperative follow-up time of 37.17 +/- 12.26 months. The poisoning symptoms of 
      TB were relieved in all patients, and ESR (42.09 +/- 9.53 vs 8.04 +/- 5.41, P < 0.05) 
      and CRP (30.37 +/- 16.02 vs 7.4 +/- 2.68, P < 0.05) were decreased at the 3 
      postoperative months in the comparison of the preoperative. The C0-C2 Cobb angle, 
      C2-C7 Cobb angle, local Cobb angle, SCA, TIS, C2-C7 SVA, and CGH-C7 SVA were 
      corrected remarkably after surgery (P < 0.05). Further, there was a significant 
      improvement in the JOA, VAS, and NDI with the comparison of the preoperative 
      (P < 0.05). CONCLUSIONS: Anterior debridement and BFIF combined with anti-TB 
      chemotherapy was a practical tool for the treatment of SCS-TB with the help of 
      SCS sagittal parameters, which can remove the lesion completely, decompress the 
      spinal cord compression, and correct the kyphotic deformity to restore the spine 
      sagittal balance.
CI  - (c) 2022. The Author(s).
FAU - Luan, Haopeng
AU  - Luan H
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Liu, Kai
AU  - Liu K
AD  - Department of Trauma and Microreconstructive Surgery, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Kahaer, Alafate
AU  - Kahaer A
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Sheng, Weibin
AU  - Sheng W
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Maimaiti, Maierdan
AU  - Maimaiti M
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Deng, Qiang
AU  - Deng Q
AD  - Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China. 1714250017@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20220427
PL  - England
TA  - BMC Surg
JT  - BMC surgery
JID - 100968567
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Adult
MH  - Antitubercular Agents/therapeutic use
MH  - *Bone Transplantation
MH  - Debridement
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Tuberculosis, Spinal/surgery
PMC - PMC9044884
OTO - NOTNLM
OT  - Anterior surgery
OT  - Internal fixation
OT  - Subaxial cervical spine
OT  - Tuberculosis
COIS- The authors declare that they have no competing interests.
EDAT- 2022/04/29 06:00
MHDA- 2022/04/30 06:00
PMCR- 2022/04/27
CRDT- 2022/04/28 05:09
PHST- 2022/03/31 00:00 [received]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/04/28 05:09 [entrez]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2022/04/27 00:00 [pmc-release]
AID - 10.1186/s12893-022-01606-y [pii]
AID - 1606 [pii]
AID - 10.1186/s12893-022-01606-y [doi]
PST - epublish
SO  - BMC Surg. 2022 Apr 27;22(1):150. doi: 10.1186/s12893-022-01606-y.