PMID- 35477738
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Apr 27
TI  - Intravascular polarization-sensitive optical coherence tomography based on 
      polarization mode delay.
PG  - 6831
LID - 10.1038/s41598-022-10709-8 [doi]
LID - 6831
AB  - Intravascular polarization-sensitive optical coherence tomography (IV-PSOCT) 
      provides depth-resolved tissue birefringence which can be used to evaluate the 
      mechanical stability of a plaque. In our previous study, we reported a new 
      strategy to construct polarization-sensitive optical coherence tomography in a 
      microscope platform. Here, we demonstrated that this technology can be 
      implemented in an endoscope platform, which has many clinical applications. A 
      conventional intravascular OCT system can be modified for IV-PSOCT by introducing 
      a 12-m polarization-maintaining fiber-based imaging probe. Its two polarization 
      modes separately produce OCT images of polarization detection channels spatially 
      distinguished by an image separation of 2.7 mm. We experimentally validated our 
      IV-PSOCT with chicken tendon, chicken breast, and coronary artery as the image 
      samples. We found that the birefringent properties can be successfully visualized 
      by our IV-PSOCT.
CI  - (c) 2022. The Author(s).
FAU - Li, Yan
AU  - Li Y
AD  - Beckman Laser Institute, University of California, Irvine, Irvine, CA, 92617, 
      USA.
FAU - Moon, Sucbei
AU  - Moon S
AD  - Department of Physics, Kookmin University, Seoul, 02707, South Korea.
FAU - Jiang, Yuchen
AU  - Jiang Y
AD  - Beckman Laser Institute, University of California, Irvine, Irvine, CA, 92617, 
      USA.
AD  - Department of Physics, Kookmin University, Seoul, 02707, South Korea.
FAU - Qiu, Saijun
AU  - Qiu S
AD  - Beckman Laser Institute, University of California, Irvine, Irvine, CA, 92617, 
      USA.
AD  - Department of Biomedical Engineering, University of California, Irvine, Irvine, 
      CA, 92697, USA.
FAU - Chen, Zhongping
AU  - Chen Z
AD  - Beckman Laser Institute, University of California, Irvine, Irvine, CA, 92617, 
      USA. z2chen@uci.edu.
AD  - Department of Biomedical Engineering, University of California, Irvine, Irvine, 
      CA, 92697, USA. z2chen@uci.edu.
AD  - The Cardiovascular Innovation and Research Center, University of California, 
      Irvine, , Irvine, CA, 92617, USA. z2chen@uci.edu.
LA  - eng
GR  - R01HL-125084/NH/NIH HHS/United States
GR  - 20POST35200050/AHA/American Heart Association-American Stroke Association/United 
      States
GR  - R01EB-030024/NH/NIH HHS/United States
GR  - R01EY-026091/NH/NIH HHS/United States
GR  - R01 HL127271/HL/NHLBI NIH HHS/United States
GR  - R01 HL125084/HL/NHLBI NIH HHS/United States
GR  - R01HL-127271/NH/NIH HHS/United States
GR  - R01 EB030558/EB/NIBIB NIH HHS/United States
GR  - R01 EB030024/EB/NIBIB NIH HHS/United States
GR  - R01EY-028662/NH/NIH HHS/United States
GR  - R01 EY028662/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220427
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Birefringence
MH  - Coronary Vessels
MH  - *Refraction, Ocular
MH  - Tendons
MH  - *Tomography, Optical Coherence/methods
PMC - PMC9046432
COIS- The authors declare no competing interests. Dr. Sucbei Moon was a visiting 
      researcher at Beckman Laser Institute, University of California, Irvine.
EDAT- 2022/04/29 06:00
MHDA- 2022/04/30 06:00
PMCR- 2022/04/27
CRDT- 2022/04/28 05:26
PHST- 2021/09/18 00:00 [received]
PHST- 2022/04/11 00:00 [accepted]
PHST- 2022/04/28 05:26 [entrez]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2022/04/27 00:00 [pmc-release]
AID - 10.1038/s41598-022-10709-8 [pii]
AID - 10709 [pii]
AID - 10.1038/s41598-022-10709-8 [doi]
PST - epublish
SO  - Sci Rep. 2022 Apr 27;12(1):6831. doi: 10.1038/s41598-022-10709-8.