PMID- 35478043
OWN - NLM
STAT- MEDLINE
DCOM- 20220811
LR  - 20220811
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 279
IP  - 9
DP  - 2022 Sep
TI  - Prognostic value of a microRNA-pair signature in laryngeal squamous cell 
      carcinoma patients.
PG  - 4451-4460
LID - 10.1007/s00405-022-07404-9 [doi]
AB  - PURPOSE: Predicting the prognosis in laryngeal squamous cell carcinoma (LSCC) 
      patients will improve clinical decision-making. Here, we aimed to identify a 
      qualitative signature based on the within-sample relative expression orderings 
      (REOs) of microRNA (miRNA) pairs to predict the overall survival (OS) of LSCC 
      patients. METHODS: First, we constructed non-repeating miRNA pairs based on 
      differentially expressed miRNAs (DEmiRNAs) between LSCC and normal tissues. Then, 
      we applied a bootstrap-based feature selection method to identify a robust 
      miRNA-pair signature. The bootstrap-based feature selection improved the 
      stability of feature selection by an ensemble based on the data perturbation. 
      Furthermore, a series of bioinformatics analyses were carried out to explore the 
      potential mechanisms of the signature and potential drug targets for LSCC. 
      RESULTS: Based on the REOs of miRNA pairs, we identified a qualitative signature 
      that consisted of 12 miRNA pairs. The constructed signature has good performance 
      in predicting the OS of LSCC patients. It is robust against batch effects and 
      more suitable for individual clinical applications. Furthermore, we identified 
      several hub genes that may be potential drug targets for LSCC. CONCLUSION: 
      Overall, our findings provided a promising signature for predicting the OS of 
      LSCC patients.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhou, Shu
AU  - Zhou S
AUID- ORCID: 0000-0002-9211-0535
AD  - Central Laboratory, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Shenzhen, China. shuzhou2007@126.com.
AD  - Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced 
      Technology, Chinese Academy of Sciences, Shenzhen, China. shuzhou2007@126.com.
FAU - Meng, Qingchun
AU  - Meng Q
AD  - Central Laboratory, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Shenzhen, China.
FAU - Wang, Zexuan
AU  - Wang Z
AD  - Central Laboratory, National Cancer Center/National Clinical Research Center for 
      Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Shenzhen, China.
LA  - eng
GR  - SZSM201812062/Sanming Project of Medicine in Shenzhen/
GR  - SZSM201612097/Sanming Project of Medicine in Shenzhen/
PT  - Journal Article
DEP - 20220427
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - *Carcinoma, Squamous Cell/genetics/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - *Head and Neck Neoplasms/genetics
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics/pathology
MH  - *MicroRNAs/genetics/metabolism
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
OTO - NOTNLM
OT  - Feature selection
OT  - Laryngeal squamous cell carcinoma
OT  - MicroRNA
OT  - Relative expression ordering
OT  - Signature
EDAT- 2022/04/29 06:00
MHDA- 2022/08/12 06:00
CRDT- 2022/04/28 05:40
PHST- 2022/02/16 00:00 [received]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/08/12 06:00 [medline]
PHST- 2022/04/28 05:40 [entrez]
AID - 10.1007/s00405-022-07404-9 [pii]
AID - 10.1007/s00405-022-07404-9 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4451-4460. doi: 
      10.1007/s00405-022-07404-9. Epub 2022 Apr 27.