PMID- 35479659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220718
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Characteristics of the Fractional Amplitude of Low-Frequency Fluctuation in 
      Ocular Hypertension Patients: A Resting-State fMRI Study.
PG  - 687420
LID - 10.3389/fmed.2021.687420 [doi]
LID - 687420
AB  - BACKGROUND: The fractional amplitude of low-frequency fluctuation (fALFF) method 
      has been underutilized in research on the pathogenesis and clinical 
      manifestations of ocular hypertension (OH). PURPOSE: This study uses resting 
      state functional magnetic resonance imaging (rs-fMRI) and fALFF to investigate 
      the nature of spontaneous brain activity in OH patients and the relationship, if 
      any, between changes in activity and clinical features. MATERIALS AND METHODS: A 
      total of 18 subjects (9 females and 9 males) with ocular hypertension (OH) and 18 
      healthy controls (HCs) matched for gender, age, and educational level were 
      recruited to this study. All participants underwent an rs-fMRI scan, and 
      spontaneous brain activity was assessed using the fALFF method. Receiver 
      operating characteristic curves were plotted to investigate differences between 
      OH and HC groups. RESULTS: The fALFF values of OH patients were significantly 
      higher in the left precuneus lobe (LP), compared with the same region in controls 
      (P < 0.05). Conversely, values in the left anterior cingulate lobe (LAC), were 
      significantly lower (P < 0.05) in OH than in controls. However, no significant 
      association was found between the mean fALFF values and clinical characteristics 
      in either brain area. CONCLUSION: High spontaneous activity in two brain areas 
      may reflect neuropathological mechanisms underpinning visual impairment in OH 
      patients.
CI  - Copyright (c) 2022 Liang, Pan, Shu, Chou, Ge, Zhang, Li, Liang, Li and Shao.
FAU - Liang, Ying
AU  - Liang Y
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Pan, Yi-Cong
AU  - Pan YC
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Shu, Hui-Ye
AU  - Shu HY
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Chou, Xue-Mei
AU  - Chou XM
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Ge, Qian-Min
AU  - Ge QM
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Zhang, Li-Juan
AU  - Zhang LJ
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Li, Qiu-Yu
AU  - Li QY
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Liang, Rong-Bing
AU  - Liang RB
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Li, Han-Lin
AU  - Li HL
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
FAU - Shao, Yi
AU  - Shao Y
AD  - Department of Ophthalmology, The First Affiliated Hospital of Nanchang 
      University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical 
      Research Centre, Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20220408
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
EIN - Front Med (Lausanne). 2022 Jun 29;9:958937. PMID: 35847792
PMC - PMC9037746
OTO - NOTNLM
OT  - fractional amplitude of low-frequency fluctuation
OT  - left anterior cingulate cortex
OT  - left precuneus
OT  - ocular hypertension
OT  - resting state functional magnetic resonance imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/29 06:00
MHDA- 2022/04/29 06:01
PMCR- 2022/04/08
CRDT- 2022/04/28 06:21
PHST- 2021/03/29 00:00 [received]
PHST- 2021/12/27 00:00 [accepted]
PHST- 2022/04/28 06:21 [entrez]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/04/29 06:01 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - 10.3389/fmed.2021.687420 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Apr 8;8:687420. doi: 10.3389/fmed.2021.687420. 
      eCollection 2021.